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Abstract
Previous measurements of the washout of 133Xe from the lung have been confined largely to the determination of the clearance
constant from the entire lung or from a number of specific sites. The present investigation
demonstrates that a sufficient number of Xe washout curves can be simultaneously recorded
so that a complete functional visualization of the lung can be described with a display
of the disappearance constant at each site similar to a conventional scan of the distribution
of radioactivity deposited in that organ. This object has been accomplished by calculating
washout curves for each element of a scintillation camera field following perfusion
of the lungs with dissolved 133Xe injected intravenously. Serial scans of the 133Xe distribution were obtained at time intervals sufficiently short so that the clearance
rate could be established and the initial distribution determined. The Xe disappearance
rates at each camera element were obtained by least-squares fitting of the logarithm
of the counts collected at each element during the interval of each frame. In order
to integrate visually the variation of clearance at each site, both numerical matrices
and 3 dimensional models of initial distribution and disappearance constants have
been utilized. While the spatial resolution of a functional scan cannot be expected
to equal the resolution of a distribution scan, it is believed that the ability to
present integrated information on a functional parameter of regional lung ventilation
will provide a valuable tool for the diagnosis and evaluation of various abnormalities
of this organ.
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Article info
Publication history
Accepted:
July 30,
1970
Received:
December 8,
1969
Footnotes
☆This investigation was supported in part by National Heart Institute Grant HE-06304, National Institutes of Health, United States Public Health Service, and by the Joseph H. Thompson Foundation.
Identification
Copyright
© 1970 Published by Elsevier Inc.
