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Abstract
Cholesterol-4-14C, cholic acid-24-14C, and chenodeoxycholic acid-24-14C were administered to infants with extrahepatic biliary atresia, and excretion of
isotope in urine and feces was followed. Fifteen per cent of the administered cholesterol
was eliminated in a 17 day period. Twenty-four to 48 per cent of daily excreted isotope
was recovered from feces as neutral steroids, mainly cholesterol. The isotope in urine
consisted of labeled bile acids, mainly cholic and chenodeoxycholic acid. A minor
part of the urinary isotope consisted of a complex mixture of different bile acids.
After administration of cholic acid-24-14C, 55 to 77 per cent of the isotope was excreted in urine in a 4 day period. Chenodeoxycholic
acid-24-14C was excreted very slowly and only 15 to 17 per cent of the isotope was excreted
in a 4 day period. Less than 3 per cent of the administered isotope was excreted in
feces. Cholic acid was found to be a metabolic end product, whereas 4 to 7 per cent
of chenodeoxycholic acid was transformed prior to urinary excretion.
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Article info
Publication history
Accepted:
April 28,
1971
Received:
January 4,
1971
Footnotes
☆This work has been supported by grants from the Swedish Medical Research Council (602) and from Stockholms Läns Landsting.
Identification
Copyright
© 1971 Published by Elsevier Inc.
