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Abstract
The concentrations and renal clearances of 13 plasma proteins were measured in 5 patients
with diseases which affect the renal tubules. Two patients with Fanconi syndrome were
each studied once. Two patients with tubular necrosis and one with both tubular necrosis
and intravascular coagulation were investigated, both in the early diuretic phase,
and after the return of renal function to normal. There was a lack of any consistent
relationship between the molecular weight of an individual protein and its relative
clearance, and individual proteins of similar molecular weight appeared to be handled
differently by the kidney. The urines were also analyzed by Sephadex G-75 gel filtration.
Five elution peaks were obtained; the most prominent peaks were the albumin and 50,000
molecular weight peaks which contained approximately equal amounts of protein. With
the exception of one urine, there was little evidence that the 50,000 molecular weight
peak contained fragments of larger molecules. The character of the proteinuria in
these patients differs from that described in health, after exercise, and in patients
with diseases affecting the glomeruli.
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Article info
Publication history
Accepted:
May 26,
1971
Received:
December 23,
1970
Footnotes
☆Supported by National Institutes of Health Grants No. AM 10314, AM 12330 and the Henry P. Shapiro Renal Fund.
Identification
Copyright
© 1971 Published by Elsevier Inc.
