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Abstract
Studies were performed with the isolated, in situ guinea pig gallbladder to determine
the effects of gallbladder injury on absorption of organic onions. Spontaneous cholelithiasis
with chronic cholecystitis was accompanied by a decrease in absorption of all compounds
studied. Spontaneous acute cholecystitis caused markedly increased absorption of taurocholate,
sulfobromophthalein, and iodipamide but did not affect absorption of unconjugated
bilirubin. Mucosal injury, ranging from epithelial flattening to acute mucosal inflammation
to hemorrhagic mucosal necrosis, was produced experimentally by solutions of pure
bile salts. The grade of injury, increased with time of exposure and bile salt concentration,
was more severe with unconjugated than conjugated bile salts and was diminished by
addition of bilirubin to the bile salt solution. The mucosal inflammatory lesion,
which resembled spontaneous acute cholecystitis, similarly markedly increased absorption
of taurocholate but left bilirubin absorption unchanged. Mucosal damage by bile salts
and a consequent selective increase in bile salt absorption might play a role in the
pathogenesis of cholesterol gallstones.
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Article info
Publication history
Accepted:
May 5,
1971
Received:
February 15,
1971
Footnotes
☆This work was supported by a research grant (AM-06840) from the National Institutes of Health, United States Public Health Service.
Identification
Copyright
© 1971 Published by Elsevier Inc.