Research Article| Volume 78, ISSUE 2, P255-264, August 1971

Absorption of organic compounds by the injured gallbladder

  • J.Donald Ostrow
    Reprint requests: Dr. J. Donald Ostrow, University of Pennsylvania Medical Service, Veterans Administration Hospital, Philadelphia, Pa. 19104.
    From the Department of Medicine, Case-Western Reserve University School of Medicine Cleveland, Ohio, USA

    From the University Hospitals of Cleveland Cleveland, Ohio, USA
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      Studies were performed with the isolated, in situ guinea pig gallbladder to determine the effects of gallbladder injury on absorption of organic onions. Spontaneous cholelithiasis with chronic cholecystitis was accompanied by a decrease in absorption of all compounds studied. Spontaneous acute cholecystitis caused markedly increased absorption of taurocholate, sulfobromophthalein, and iodipamide but did not affect absorption of unconjugated bilirubin. Mucosal injury, ranging from epithelial flattening to acute mucosal inflammation to hemorrhagic mucosal necrosis, was produced experimentally by solutions of pure bile salts. The grade of injury, increased with time of exposure and bile salt concentration, was more severe with unconjugated than conjugated bile salts and was diminished by addition of bilirubin to the bile salt solution. The mucosal inflammatory lesion, which resembled spontaneous acute cholecystitis, similarly markedly increased absorption of taurocholate but left bilirubin absorption unchanged. Mucosal damage by bile salts and a consequent selective increase in bile salt absorption might play a role in the pathogenesis of cholesterol gallstones.
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