Serum transcobalamin in myeloid leukemia

B. Rachmilewitz; M. Rachmilewitz; B. Moshkowitz; J. Gross

doi:10.5555/uri:pii:0022214371902265

Research Article| Volume 78, ISSUE 2, P275-288, August 1971

Serum transcobalamin in myeloid leukemia

B. Rachmilewitz
B. Rachmilewitz
Correspondence
Reprint requests: B. Rachmilewitz, Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, P. O. Box 1172, Jerusalem, Israel.
Affiliations
From the Medical Research Laboratory and the Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School Jerusalem, Israel
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M. Rachmilewitz
M. Rachmilewitz
Affiliations
From the Medical Research Laboratory and the Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School Jerusalem, Israel
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B. Moshkowitz
B. Moshkowitz
Affiliations
From the Medical Research Laboratory and the Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School Jerusalem, Israel
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J. Gross
J. Gross
Affiliations
From the Medical Research Laboratory and the Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School Jerusalem, Israel
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DOI:https://doi.org/10.5555/uri:pii:0022214371902265

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Abstract

The determination of serum vitamin B₁₂ concentrations, unsaturated B₁₂ binding capacity, and total B₁₂ binding capacity of whole serum and of the separate transcobalamin I and transcobalalamin II fractions has shown that the increased B₁₂ binding capacity of serum proteins in chronic myeloid leukemia is due mainly to an increase in transcobalamin I. Transcobalamin II is relatively unchanged. Serum B₁₂ concentrations and unsaturated B₁₂ binding capacity are only slightly elevated in acute myeloblastic leukemia; total binding capacity of transcobalamin I is within the normal range. The findings observed in acute promyelocytic leukemia are similar to those found in chronic myeloid leukemia. These observations suggest that the excessive amounts of transcobalamin I in chronic myeloid leukemia are produced by proliferating and differentiated myeloid cells beginning at the promyelocytic stage. Transcobalamin I is decreased markedly following the administration of cytotoxic agents.

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Article info

Publication history

Accepted: April 28, 1971

Received: October 30, 1970

Footnotes

☆This work constitutes part of the Ph.D. program of B. Rachmilewitz.

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DOI: https://doi.org/10.5555/uri:pii:0022214371902265

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Serum transcobalamin in myeloid leukemia

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References

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