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Abstract
Rabbit erythrocytes rich in reticulocytes are able to synthesize long-chain fatty
acids from either acetate or acetyl coenzyme A. This is due to the presence of the
enzyme acetyl coenzyme A carboxylase, which is absent in the mature erythrocyte. This
enzymatic activity can be shown to fall to zero as the erythrocyte population matures.
In common with other tissues, acetyl coenzyme A carboxylase in immature erythrocytes
is a biotin enzyme system and requires ATP, HCO3−, and Mn++; and is stimulated by acids of the tricarboxylic acid cycle. Preliminary evidence
is also presented suggesting the presence of this enzyme in an erythrocyte extract
of a patient with a high reticulocyte count.
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Article info
Publication history
Accepted:
September 29,
1972
Received:
June 21,
1972
Footnotes
☆Supported by Grants from National Institutes of Health No AM13774-02 and AM05205-12, National Science Foundation No. BO19636, and Research Grants from the American Diabetes Association and the John Hartford Foundation.
Identification
Copyright
© 1973 Published by Elsevier Inc.
