Research Article| Volume 81, ISSUE 1, P37-42, January 1973

Fatty acid biosynthesis in the erythrocyte. II. Evidence in immature erythrocytes for the presence of acetyl co-enzyme A carboxylase

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      Rabbit erythrocytes rich in reticulocytes are able to synthesize long-chain fatty acids from either acetate or acetyl coenzyme A. This is due to the presence of the enzyme acetyl coenzyme A carboxylase, which is absent in the mature erythrocyte. This enzymatic activity can be shown to fall to zero as the erythrocyte population matures. In common with other tissues, acetyl coenzyme A carboxylase in immature erythrocytes is a biotin enzyme system and requires ATP, HCO3, and Mn++; and is stimulated by acids of the tricarboxylic acid cycle. Preliminary evidence is also presented suggesting the presence of this enzyme in an erythrocyte extract of a patient with a high reticulocyte count.
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