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Abstract
Clearance of muramidase (lysozyme) was studied in the normal and chloroma-bearing
rat. The chloroma-bearing rat often develops a leukemic blood picture resembling human
acute myelogenous leukemia and demonstrates markedly elevated serum and urinary muramidase
activity. Both solid tumor bearing, nonleukemic (chloromatous) rats and acutely leukemic
(chloroleukemic) rats were studied. Intravenously injected, purified rat muramidase
was rapidly cleared from normal and leukemic rats. However, nonleukemic chloroma-bearing
animals, known to have chronically elevated serum muramidase levels showed delayed
enzyme clearance. These observations support the theory that chronic, but not acute,
elevation of enzyme activity can overload the mechanism for renal muramidase degradation.
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References
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Article info
Publication history
Accepted:
October 4,
1972
Received:
November 22,
1971
Footnotes
☆This investigation was supported by United States Public Health Service Grants CA 05691-05 and C 6516 from the National Cancer Institute, the Nehemias Gorin Foundation, and the American Cancer Society (Massachusetts Division), Grant No. 1410-C1.
Identification
Copyright
© 1973 Published by Elsevier Inc.
