Heterogeneity of red cell glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Egypt

Paul R. McCurdy; Karim Kamel; Osaïma Selim

doi:10.5555/uri:pii:0022214374901437

Research Article| Volume 84, ISSUE 5, P673-680, November 1974

Heterogeneity of red cell glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Egypt

Paul R. McCurdy
Paul R. McCurdy
Correspondence
Reprint requests: Dr. Paul R. McCurdy, District of Columbia General Hospital 19 St. and Massachussetts Ave., SE Washington, D. C. 20003.
Footnotes
Affiliations
From the Georgetown Medical Division, District of Columbia General Hospital, Washington, D. C., USA
From the Ain-Shams Medical School, Cairo, Arab Republic of Egypt
From the United States Naval Medical Research Unit No. 3, (NAMRU-3), Cairo, Egypt
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Karim Kamel
Karim Kamel
Footnotes
Affiliations
From the Georgetown Medical Division, District of Columbia General Hospital, Washington, D. C., USA
From the Ain-Shams Medical School, Cairo, Arab Republic of Egypt
From the United States Naval Medical Research Unit No. 3, (NAMRU-3), Cairo, Egypt
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Osaïma Selim
Osaïma Selim
Affiliations
From the Georgetown Medical Division, District of Columbia General Hospital, Washington, D. C., USA
From the Ain-Shams Medical School, Cairo, Arab Republic of Egypt
From the United States Naval Medical Research Unit No. 3, (NAMRU-3), Cairo, Egypt
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Author Footnotes
∗ Professor of Medicine, Georgetown University School of Medicine, Washington, D. C.
∗∗ Associate Professor, Clinical Pathology, Ain-Shams University Medical School, Cairo, Arab Republic of Egypt; Expert Advisor, NAMRU-3, Cairo, Egypt. Present address: Associate professor, Department of Pathology, Medical College of Georgia, Augusta, Ga. 30902.

DOI:https://doi.org/10.5555/uri:pii:0022214374901437

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Abstract

Glucose-6-phosphate dehydrogenase (G-6-PD) was partially purified from blood of 52 Egyptian males and the variants characterized biochemically and electrophoretically. Subjects were from multiple geographic regions within Egypt. There were 18 abnormal variants plus the normal G-6-PD B+ (9 subjects). Previously described variants were G-6-PD's A+ (2), Ibadan-Austin (2), Debrousse (5), A- (1), Ramat-Gan (6), “Athens-like” (4), Mediterranean (3), Kabyle (2), Tel-Hashomer (3), Ohio (2), Chicago (1), Madrona (1), and West Bengal (1). Four new variants were characterized: G-6-PD's Tahta, Siwa, El-Kharga, and El-Fayoum. G-6-PD deficiency in Egypt, as elsewhere, is a heterogeneous defect.

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Article info

Publication history

Accepted: July 9, 1974

Received: April 8, 1974

Footnotes

☆Supported in part by Grant AM09307 from the National Institutes of Health, Bethesda, Md., and in part by Office of Naval Research Contract No. N00014-70-C-0192, NR 108-885.

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Heterogeneity of red cell glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Egypt

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