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Abstract
We studied the effects of insulin, epinephrine, and clofibrate on the activities of
carbohydrate-metabolizing enzymes in adipose tissue of 8 obese human volunteer subjects.
In all patients, clofibrate decreased the activities of pyruvate kinase, phosphofructokinase,
fructose diphosphate aldolase, and fructose diphosphatase after 7 days of treatment.
In 4 patients studied in more detail, insulin produced a significant increase in pyruvate
kinase and phosphofructokinase activities and a significant decrease in fructose diphosphatase
within 5 minutes. Epinephrine injection produced opposite effects. Clofibrate decreased
these responses to both insulin and epinephrine. Clofibrate may act at the plasma
membrane of the adipose cell to inhibit the lipolytic effects of epinephrine and the
antilipolytic effects of insulin.
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Article info
Publication history
Accepted:
July 2,
1974
Received:
December 3,
1973
Footnotes
☆The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Identification
Copyright
© 1974 Published by Elsevier Inc.
