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The oxyhemoglobin dissociation curve in patients with familial hyperchylomicronemia

  • Jørn Ditzel
    Correspondence
    Reprint requests: Dr. Jørn Ditzel, Section of Endocrinology and Metabolism, Department of Medicine, Aalborg Regional Hospital, 9000 Denmark.
    Affiliations
    From the Section of Endocrinology and Metabolism, Department of Medicine, Aalborg, Denmark

    From the Department of Clinical Chemistry, Aalborg Regional Hospital, Aalborg, Denmark
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  • Jørn Dyerberg
    Affiliations
    From the Section of Endocrinology and Metabolism, Department of Medicine, Aalborg, Denmark

    From the Department of Clinical Chemistry, Aalborg Regional Hospital, Aalborg, Denmark
    Search for articles by this author
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      Abstract

      In order to study the effect of marked chylomicronemia on red cell oxygen release, oxygen hemoglobin dissociation curves (ODC's) from zero to full saturation were determined on whole blood from three siblings with familial Type I hyperlipoproteinemia. In these cases the oxygen affinity of hemoglobin was markedly increased, with P50 act. pH varying between 22.1 and 17.7 mm. Hg (normal value, 27.3 mm. Hg; S.D., 1.3) and the Hill coefficient n reflecting the slope of the ODC was increased. The changes in the ODC's are thought to be secondary to the hyperchylomicronemia for the following reasons: (1) the change was minimized by incubating red cells from the patients in normal donor plasma; (2) normal red cells increased their oxygen affinity when incubated in lactescent plasma; (3) the change was not explainable by a decrease in red cell 2,3-diphosphoglycerate content or in arterial blood hydrogen ion concentration. Based on these findings a decreased erythrocyte oxygen release of one third can be hypothesized. The importance of this observation in relation to the symptomatology of clinical conditions complicating marked chylomicronemia is discussed.
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