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Abstract
In order to study the effect of marked chylomicronemia on red cell oxygen release,
oxygen hemoglobin dissociation curves (ODC's) from zero to full saturation were determined
on whole blood from three siblings with familial Type I hyperlipoproteinemia. In these
cases the oxygen affinity of hemoglobin was markedly increased, with P50 act. pH varying between 22.1 and 17.7 mm. Hg (normal value, 27.3 mm. Hg; S.D., 1.3)
and the Hill coefficient n reflecting the slope of the ODC was increased. The changes
in the ODC's are thought to be secondary to the hyperchylomicronemia for the following
reasons: (1) the change was minimized by incubating red cells from the patients in
normal donor plasma; (2) normal red cells increased their oxygen affinity when incubated
in lactescent plasma; (3) the change was not explainable by a decrease in red cell
2,3-diphosphoglycerate content or in arterial blood hydrogen ion concentration. Based
on these findings a decreased erythrocyte oxygen release of one third can be hypothesized.
The importance of this observation in relation to the symptomatology of clinical conditions
complicating marked chylomicronemia is discussed.
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References
- Inhibitory effect of plasma triglycerides on oxygen release from blood in patients with hyperlipoproteinemias (abst.).Diabetologia. 1975; 11: 338
- Evidence of an interference in oxygen exchange from erythrocytes to tissues in hypertriglyceridemia.in: Proc 1st World Congress on Microcirculation, Toronto, 1975 Plenum Press, New York1976
- Familiär hyperkylomikronämi eller type I hyperlipoproteinämi.Ugeskr Läger. 1974; 136: 125-129
- A simplified method for the determination of total cholesterol in serum and demonstration of its specificity.J Biol Chem. 1952; 195: 357-366
- Eine neue Bestimmung der Neutralfette im Blutserum und Gewebe. I. Prinzip, Durchführung und Besprechung der Methode.Klin Wochenschr. 1966; 44: 262-269
- Quantitative plasma lipoprotein estimation by agarose gel electrophoresis.Clin Chim Acta. 1970; 28: 203-208
- A modified method for the determination of 2,3-diphosphoglycerate in erythrocytes.Scand J Clin Lab Invest. 1972; 29: 85-90
- Serum inorganic phosphorus determination using p-phenylenediamine as a reducing agent.Clin Chim Acta. 1970; 27: 373-377
- An oxyhemoglobin dissociation analyzer.J Appl Physiol. 1970; 28: 227-233
- Hb. affinity for O2 determined by O2-Hb dissociation analyzer.J Appl Physiol. 1971; 30: 903-904
- Plasma lipid and lipoprotein levels in childhood and adolescence.Scand J Clin Lab Invest. 1973; 31: 473-479
- Observation implicating that familial type I hyperlipoproteinemia is not posdipase deficient condition.in: Schettler G Weitzel H Atherosclerosis III. Springer Verlag, Berlin1974: 553-556
- Studies on the elimination of exogenous lipids from the blood stream. The kinetics of the elimination of a fat emulsion and of chylomicrons in the dog after single injection.Acta Physiol Scand. 1963; 59: 52-61
- Studies on the elimination of exogenous lipids from the blood stream. The kinetics of the elimination of a fat emulsion studied by single injection technique in man.Acta Physiol Scand. 1965; 64: 306-313
- Oxygen Diffusion in Human Blood Plasma.in: Ph.D. thesis. Northwestern University, Evanston, Ill1975
- The in vitro interchange of cholesterol between plasma and red cells.in: Proc Soc Exp Biol Med. 78. 1951: 329-332
- Erythrocyte metabolism. IV. Equilibrium of cholesterol-4-C14 between erythrocytes and various treated sera.J Lab Clin Med. 1962; 60: 571-578
- Phospholipid exchange between plasma and erythrocytes in man and the dog.J Clin Invest. 1968; 47: 749-760
- Interaction of individual phospholipids between rat plasma and erythrocytes.Biochim Biophys Acta. 1965; 98: 356-364
- Erythrocyte membranes-effect of increased cholesterol content on permeability.Biochim Biophys Acta. 1971; 249: 647-650
- The transfer of lipids between human a-lipoprotein and erythrocytes.Biochim Biophys Acta. 1964; 84: 182-187
- Exchange of cholesterol between human β-lipoproteins and erythrocytes.Biochim Biophys Acta. 1964; 84: 764-766
- Erythrocyte stromal lipids in hyperlipemic states.J Lab Clin Med. 1968; 71: 448-454
- Erythrocyte membrane lipid composition in exogenous and endogenous hypertriglyceridemia.J Lab Clin Med. 1970; 75: 53-60
- Angina pectoris induced by fat ingestion in patients with coronary artery disease.JAMA. 1955; 158: 1008-1013
- Effect of heparin on lipemia-induced angina pectoris.JAMA. 1957; 163: 727-730
- The effect of lipemia upon coronary and peripheral arterial circulation in patients with essential hyperlipemia.Am J Med. 1959; 26: 59-75
- Hyperlipemia: A cause of decreased oxygen saturation.Nature. 1963; 200: 684
- Effect of lipemia on arterial oxygen at high altitude.J Appl Physiol. 1959; 14: 894-896
- Hyperlipidemia and arterial blood gases.Dan Med Bull. 1972; 19: 167-169
- Normal arterial blood gases during experimental hypertriglyceridemia in the rat.Scand J Clin Lab Invest. 1975; 35: 645-648
- The effect of lipemia upon tissue oxygen tension in man.Circulation. 1960; 22: 901-907
- Relationship between relapsing pancreatitis and essential hyperlipemia.Am J Med. 1952; 12: 3-23
- Fat transport in lipoproteins.N Engl J Med. 1967; 276: 34-44
- Fat transport in lipoproteins.N Engl J Med. 1967; 276: 94-103
- Fat transport in lipoproteins.N Engl J Med. 1967; 276: 148-156
- Fat transport in lipoproteins.N Engl J Med. 1967; 276: 215-226
- Fat transport in lipoproteins.N Engl J Med. 1967; 276: 273-281
- Pathogenesis, differentration and management of hypertriglyceridemia.Adv Intern Med. 1969; 15: 117-154
- Acute pancreatitis with hyperlipemia.Surgery. 1971; 70: 53-61
- Hyperliproteinemia and pancreatitis.Am J Med. 1973; 54: 161-165
- Microcirculatory effects of emulsified fat infusions.Circ Res. 1964; 15: 124-130
- Microcirculatory changes in rabbit ear chambers following the infusion of fat emulsions.Metabolism. 1967; 16: 473-481
- Rheologische Aspekte der Blutströmung in Capillaren bei Lipämie.Klin Wochenschr. 1970; 48: 723-728
- Increased blood cell agglutination following ingestion of fat. A factor contributing to cardiac ischemia, coronary insufficiency, and angina pain.Angiology. 1957; 8: 29-40
Article info
Publication history
Accepted:
June 10,
1976
Received:
February 17,
1976
Footnotes
☆This study was supported in part by grants from the Danish Heart Association, Novo fund, Aalborg City, and Northern Jutland County Research funds.
☆☆Presented in part at the Thirty-fourth Nordic Congress for Internal Medicine, Aalborg, Denmark, 1974, and the first World Congress on Microcirculation, Toronto, Canada, 1975.
Identification
Copyright
© 1977 Published by Elsevier Inc.