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Original article| Volume 96, ISSUE 5, P922-932, November 1980

The induction of gastric mucosal tolerance to alcohol by chronic administration

  • Kevin J. Ivey
    Correspondence
    Reprint requests: Kevin J. Ivey, M.D., University of California, Department of Medicine, Division of Gastroenterology, Irvine, Calif. 92717.
    Affiliations
    From the Department of Medicine, The Harry S. Truman Memorial Veterans Hospital, and the University of Missouri School of Medicine, Columbia, Mo. U.S.A.

    From the Long Beach Veterans Administration Hospital and the University of California, Irvine, Calif. U.S.A.
    Search for articles by this author
  • A. Tarnawski
    Affiliations
    From the Department of Medicine, The Harry S. Truman Memorial Veterans Hospital, and the University of Missouri School of Medicine, Columbia, Mo. U.S.A.

    From the Long Beach Veterans Administration Hospital and the University of California, Irvine, Calif. U.S.A.
    Search for articles by this author
  • J. Stachura
    Affiliations
    From the Department of Medicine, The Harry S. Truman Memorial Veterans Hospital, and the University of Missouri School of Medicine, Columbia, Mo. U.S.A.

    From the Long Beach Veterans Administration Hospital and the University of California, Irvine, Calif. U.S.A.
    Search for articles by this author
  • H. Werner
    Affiliations
    From the Department of Medicine, The Harry S. Truman Memorial Veterans Hospital, and the University of Missouri School of Medicine, Columbia, Mo. U.S.A.

    From the Long Beach Veterans Administration Hospital and the University of California, Irvine, Calif. U.S.A.
    Search for articles by this author
  • T. Mach
    Affiliations
    From the Department of Medicine, The Harry S. Truman Memorial Veterans Hospital, and the University of Missouri School of Medicine, Columbia, Mo. U.S.A.

    From the Long Beach Veterans Administration Hospital and the University of California, Irvine, Calif. U.S.A.
    Search for articles by this author
  • M. Burks
    Affiliations
    From the Department of Medicine, The Harry S. Truman Memorial Veterans Hospital, and the University of Missouri School of Medicine, Columbia, Mo. U.S.A.

    From the Long Beach Veterans Administration Hospital and the University of California, Irvine, Calif. U.S.A.
    Search for articles by this author
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      Abstract

      Acute alcohol intake produces marked damage to gastric mucosa. Whether gastric mucosa develops tolerance to repeated alcohol administration is unknown. To test this, we compared the effects of acute and chronic alcohol administration in male rats. Thirty-one Sprague-Dawley rats maintained on Chow diet received the following: group A, water for 4 weeks; group B, 50% EtOH for 4 weeks; group C, water for 4 weeks, then 8 hr prior to sacrifice 50% EtOH; group D, 50% EtOH for 4 weeks, then alcohol 8 hr prior to sacrifice. Control animals did not show macroscopic or microscopic changes in fundic or pyloric mucosa. The percentage fundic mucosa showing lesions (49%) in the acute EtOH group (group C) was significantly greater than in control (0%), chronic EtOH group (group B, 8%), and chronic plus acute EtOH (group D, 14%). Pyloric lesions were not significantly different between treatment groups C (9%), B (4%), and D (8%). Histologic changes in group C (acute alcohol) consisted of superficial erosions accompanied by severe hemorrhagic changes in the upper part of the gastric mucosa. In group B (chronic alcohol) and group D (chronic + acute alcohol) changes consisted of small superficial erosions without hemorrhagic changes. Our study shows that damage in rat gastric fundic mucosa following acute intragastric administration of EtOH is significantly less in rats receiving EtOH chronically than in rats receiving only acute EtOH. We conclude that rat gastric mucosa is capable of developing tolerance to repeated administration of 50% alcohol.

      Abbreviations:

      ethanol (EtOH) ()
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