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Abstract
The effect of OCS on the disposition and elimination of caffeine was examined. Caffeine
(250 mg) was administered orally to 13 healthy males, nine healthy females taking
no OCS, and nine healthy females on OCS. The ![Math Eq]()
was significantly prolonged in women on OCS (10.7 ± 3.0 hr vs. 6.2 ± 1.6) (p < 0.001)
as compared to women taking no OCS. Women on OCS had a significantly lower total plasma
clearance (0.79 ± 0.21 ml/min/kg vs. 1.3 ± 0.35) and free clearance (1.12 ± 0.28 ml/min/kg
vs. 1.97 ± 0.57) than women not taking OCS. Volumes of distribution and plasma binding
were similar in both groups of females. When women taking no OCS were compared with
men, all pharmacokinetic parameters were similar except for volume of distribution,
which was significantly larger in the women (p < 0.05). We conclude that OCS impair
the elimination of caffeine.
was significantly prolonged in women on OCS (10.7 ± 3.0 hr vs. 6.2 ± 1.6) (p < 0.001)
as compared to women taking no OCS. Women on OCS had a significantly lower total plasma
clearance (0.79 ± 0.21 ml/min/kg vs. 1.3 ± 0.35) and free clearance (1.12 ± 0.28 ml/min/kg
vs. 1.97 ± 0.57) than women not taking OCS. Volumes of distribution and plasma binding
were similar in both groups of females. When women taking no OCS were compared with
men, all pharmacokinetic parameters were similar except for volume of distribution,
which was significantly larger in the women (p < 0.05). We conclude that OCS impair
the elimination of caffeine.Abbreviations:
oral contraceptive steroids (OCS), elimination half-life (t12(β)), aminopyrine breath test (ABT)To read this article in full you will need to make a payment
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Article Info
Publication History
Accepted:
December 19,
1979
Received:
September 24,
1979
Footnotes
☆Supported by the Medical Research Service of the Veterans Administration and NIH Grant AA00267.
Identification
Copyright
© 1980 Published by Elsevier Inc.
