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Monocyte chemotaxis in leukemia patients

  • David A. Norris
    Correspondence
    Reprint requests: David A. Norris, M.D., Department of Dermatology, B-153, University of Colorado Health Sciences Center, 4200 East Ninth Ave., Denver, Colo. 80262.
    Affiliations
    From the Departments of Dermatology and Pediatrics, University of Colorado Health Sciences Center Denver, Colo., USA

    From the Denver Children's Hospital, Denver, Colo., USA
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  • William L. Weston
    Affiliations
    From the Departments of Dermatology and Pediatrics, University of Colorado Health Sciences Center Denver, Colo., USA

    From the Denver Children's Hospital, Denver, Colo., USA
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  • David G. Tubergen
    Affiliations
    From the Departments of Dermatology and Pediatrics, University of Colorado Health Sciences Center Denver, Colo., USA

    From the Denver Children's Hospital, Denver, Colo., USA
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  • Barbara Rose
    Affiliations
    From the Departments of Dermatology and Pediatrics, University of Colorado Health Sciences Center Denver, Colo., USA

    From the Denver Children's Hospital, Denver, Colo., USA
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  • Lorrie F. Odom
    Affiliations
    From the Departments of Dermatology and Pediatrics, University of Colorado Health Sciences Center Denver, Colo., USA

    From the Denver Children's Hospital, Denver, Colo., USA
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      Abstract

      Monocyte chemotaxis was studied in 35 patients with ALL, six with CLL, six with AML, and 10 with CML before beginning chemotherapy. Function was contrasted to age-matched control groups. Significant inhibition of chemotaxis was seen in patients with ALL (p < 0.001) and CLL (p < 0.01), whereas function in CML and AML patients was not significantly depressed. The deficient monocyte chemotaxis was not due merely to decreased percentages of peripheral blood monocytes. Thus, in addition to numerical deficiencies in monocyte numbers, qualitative deficiencies in monocyte function exist in patients with ALL and CLL.

      Abbreviations:

      Acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), antibody-dependent cellular cytotoxicity (ADCC)
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