This paper is only available as a PDF. To read, Please Download here.
Abstract
Monocyte chemotaxis was studied in 35 patients with ALL, six with CLL, six with AML,
and 10 with CML before beginning chemotherapy. Function was contrasted to age-matched
control groups. Significant inhibition of chemotaxis was seen in patients with ALL
(p < 0.001) and CLL (p < 0.01), whereas function in CML and AML patients was not significantly
depressed. The deficient monocyte chemotaxis was not due merely to decreased percentages
of peripheral blood monocytes. Thus, in addition to numerical deficiencies in monocyte
numbers, qualitative deficiencies in monocyte function exist in patients with ALL
and CLL.
Abbreviations:
Acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), antibody-dependent cellular cytotoxicity (ADCC)To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Translational ResearchAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Defective human mononuclear leukocyte chemotaxis as an index of host resistance to malignant melanoma.Clin Immunol Immunopathol. 1976; 6: 376
- Monocyte function in cancer patients.Eur J Cancer. 1977; 13: 351
- Defective monocyte function in patients with genitourinary carcinoma.J Natl Cancer Inst. 1975; 55: 1047
- Macrophage migratory dysfunction in cancer. A mechanism for subversion of surveillance.Am J Pathol. 1977; 88: 727
- Abnormal monocyte chemotactic response in cancer patients.J Natl Cancer Inst. 1974; 52: 1091
- Chemotaxis of Macrophages.in: Nelson DS Immunobiology of the Macrophage. Academic Press, Inc, New York1976: 323
- An inhibitor of macrophage chemotaxis produced by neoplasms.Science. 1976; 192: 370
- Depression of macrophage function by a factor produced by neoplasms: a mechanism for abrogation of immune surveillance.J Immunol. 1976; 117: 1243
- Cell-specific defect in monocyte function during tumor growth.J Natl Cancer Inst. 1976; 57: 135
- Subversion of host defense mechanisms by murine tumors. I. A circulating factor that suppresses macrophage-mediated resistance to infection.J Exp Med. 1976; 143: 559
- Subversion of host defense mechanisms by murine tumors. II. Counter-influence of concomitant antitumor immunity.J Exp Med. 1976; 143: 574
- Immune function of successfully treated lymphoma patients.J Clin Invest. 1977; 57: 1451
- The effect of tuberculosis and neoplasia on human monocyte staphylocidal activity.Cell Immunol. 1975; 16: 389
- Handbook of Experimental Immunology. F. A. Davis Co, Philadelphia1967: 1009
- Quantitative assays of human monocyte macrophage function.J Immunol Methods. 1975; 8: 213
- Cell-mediated immunity in human acute leukemia.Bibl Haematol. 1975; 40: 648
- Serial studies of immunocompetence of patients undergoing chemotherapy for acute leukemia.J Clin Invest. 1974; 54: 401
- In vitro evidence of normal lymphocyte function in some patients with Hodgkin's disease and negative delayed cutaneous hypersensitivity.Natl Cancer Inst Monogr. 1973; 36: 99
- Lymphocyte transformation in leukemic serum.Cancer. 1975; 35: 1341
- Quantitation of T and B lymphocytes and cellular immune function in Hodgkin's disease.Cancer. 1975; 36: 169
- B and T Cell lymphomas: analysis of blood and lymph nodes in 87 patients.Am J Med. 1975; 59: 674
- Possible role of macrophage mediated nonspecific cytotoxicity in tumor resistance.Nature. 1972; 235: 48
- Mechanisms of immunologically specific killing of tumor cells by macrophages.Nature. 1972; 236: 168
- Immunologic responses to a murine mammary adenocarcinoma. II. Monocyte effector activation by humoral factors.Int J Cancer. 1977; 19: 717
- Abnormalities of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal.J Natl Cancer Inst. 1977; 58: 37
- Defective monocyte chemotaxis in mycosis fungoides: lack of essential helper lymphocytes.Cancer. 1979; 44: 124
- Circulating immune complexes detected by 135I Clq deviation test in sera of cancer patients.J Clin Invest. 1977; 59: 1134
- Inhibition of monocyte chemotaxis by in vitro incubation with cryoimmunoglobulins from patients with malignant melanoma.J Invest Dermatol. 1979; 72: 275
- Clinical relevance of circulating immune complexes in human leukemia.J Clin Invest. 1977; 60: 874
Article info
Publication history
Accepted:
December 19,
1979
Received:
November 5,
1979
Footnotes
☆Supported in part by a program grant from the National Cancer Institute CA 12247, the Antonoff Cancer Research Grant, NIH Clinical Investigator Award 1-K08-AM00510-01, and the Mycosis Fungoides Grant 5-R01-AI13171-03.
Identification
Copyright
© 1980 Published by Elsevier Inc.