This paper is only available as a PDF. To read, Please Download here.
Abstract
The effects of different levels of nitrogen, phosphorus, and caffeine intake on calcium
balance and on certain of its components were assessed in 170 studies in normal middle-aged,
but still premenopausal women. Statistically significant negative associations with
calcium balance were found for nitrogen and for caffeine, but no effect could be found
for phosphorus. Higher nitrogen intakes were associated with proportionately higher
levels of urinary calcium; higher phosphorus intake was associated with slightly lower
levels of urinary calcium but also with slightly more intestinal secretion of calcium.
Since these two effects were opposite in direction, there was no net association of
different phosphorus intakes with calcium balance. Caffeine intake was associated
with higher levels of both urinary calcium and intestinal calcium secretion. None
of the three intake variables was associated with differences in calcium absorption
efficiency. Both the nitrogen and the caffeine effects were proportional to intake.
The magnitude of the effects observed was such that a 50% increase in intake of nitrogen
above the group mean intake value would be predicted to result in calcium balance
shift of −0.032 gm/day. For caffeine, the corresponding calcium balance shift would
be predicted to be −0.006 gm/day.
Abbreviations:
total intestinal calcium secretion (TIC) ()To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Translational ResearchAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Calcium balance and calcium requirements in middleaged women.Am J Clin Nutr. 1977; 30: 1603
- The effect of estrogens and calcium carbonate on bone loss in postmenopausal women.Ann Intern Med. 1977; 87: 649
- Prospective trial of oestrogen and calcium in postmenopausal women.Br Med J. 1977; 2: 789
- Effect of protein intake on urinary and fecal calcium and calcium retention of young adult males.J Nutr. 1970; 100: 1425
- Calcium retention in the adult human male as affected by protein intake.J Nutr. 1972; 102: 1297
- Effect of protein intake on calcium balance of young men given 500 mg calcium daily.J Nutr. 1974; 104: 695
- Metabolic responses of adolescent boys to two levels of dietary magnesium and protein. II. Effect of magnesium and protein level on calcium balance.Am J Clin Nutr. 1973; 26: 519
- Studies in calcium metabolism. I. The calciuretic effect of dietary protein.Am J Clin Nutr. 1974; 27: 584
- Studies in calcium metabolism. II. Effects of low calcium and variable protein intake on human calcium metabolism.Am J Clin Nutr. 1975; 28: 1028
- Osteoporosis, its nature and the role of diet.Postgrad Med. August, 1976; 60: 75
- Metabolic Diseases of Bone.in: ed. 6. Saunders Monographs in Clinical Orthopaedics. vol. I. W. B. Saunders Co, Philadelphia1977 (chap. 29)
- Osteoporosis: dealing with a crippling bone disease of the elderly.Geriatrics. July, 1977; 32: 41
- Osteoporosis and the slender smoker.Arch Intern Med. 1976; 136: 298
- Menopausal changes in calcium balance performance.J Lab Clin Med. 1978; 92: 953
- The colorimetric determination of phosphorus.J Biol Chem. 1925; 66: 375
- A double isotope method for measurement of intestinal absorption of calcium.J Lab Clin Med. 1965; 66: 829
- Calcium absorption as a function of calcium intake.J Lab Clin Med. 1975; 85: 881
- Secretion and excretion of calcium by the human gastrointestinal tract.J Lab Clin Med. 1964; 64: 29
- Statistical Methods.ed. 6. Iowa State University Press, Ames, Iowa1967
- Statistics in Research.Iowa State University Press, Ames, Iowa1954 (chap. 8)
- Vital and Health Statistics.DHEW Publication 77ndash;1647. 1977; (Series 11, No. 202)
- Effect of a high protein (meat) intake on calcium metabolism in man.Am J Clin Nutr. 1978; 31: 2167
- Effect of phosphorus on the absorption of calcium and on the calcium balance in man.J Nutr. 1978; 108: 447
- Long-term effects of high phosphate intake on parathyroid hormone levels and bone metabolism.Acta Orthop Scand. 1974; 45: 801
- Metabolic effects and mechanism of action of phosphate supplements.in: Hioco DJ Phosphate et Métabolisme Phosphocalcique (Proceedings of International Symposium). Laboratories Sandoz, Paris1970
- Urinary calcium excretion in human beings.N Engl J Med. 1979; 301: 535
- Effect of level of protein intake on calcium metabolism and on parathyroid and renal function in the adult human male.J Nutr. 1979; 109: 1399
- Studies on the mechanism of protein-induced hypercalciuria in older men and women.J Nutr. 1980; 110: 305
Article info
Publication history
Accepted:
July 25,
1981
Received:
February 16,
1981
Footnotes
☆Supported by U.S.P.H.S. grant AM-07912.
Identification
Copyright
© 1982 Published by Elsevier Inc.