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Original article| Volume 102, ISSUE 4, P477-486, October 1983

Evaluation of in vivo measurement of transesophageal electrical resistance as an indicator of early experimental esophageal mucosal injury

  • George W. Kidder III
    Footnotes
    Affiliations
    From the Division of Surgery, Walter Reed Army Institute of Research Washington, D. C., USA

    From the Department of Surgery, Medicine, and Clinical Investigation, Walter Reed Army Medical Center, Washington, D. C., USA
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  • Keith D. Lillemoe
    Affiliations
    From the Division of Surgery, Walter Reed Army Institute of Research Washington, D. C., USA

    From the Department of Surgery, Medicine, and Clinical Investigation, Walter Reed Army Medical Center, Washington, D. C., USA
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  • John W. Harmon
    Correspondence
    Reprint requests: LTC John W. Harmon, M.D., Director, Division of Surgery, Walter Reed Army Institute of Research, Washington, D. C. 20307.
    Affiliations
    From the Division of Surgery, Walter Reed Army Institute of Research Washington, D. C., USA

    From the Department of Surgery, Medicine, and Clinical Investigation, Walter Reed Army Medical Center, Washington, D. C., USA
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  • Corinne L. Maydonovitch
    Affiliations
    From the Division of Surgery, Walter Reed Army Institute of Research Washington, D. C., USA

    From the Department of Surgery, Medicine, and Clinical Investigation, Walter Reed Army Medical Center, Washington, D. C., USA
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  • Ralph M. Bunte
    Affiliations
    From the Division of Surgery, Walter Reed Army Institute of Research Washington, D. C., USA

    From the Department of Surgery, Medicine, and Clinical Investigation, Walter Reed Army Medical Center, Washington, D. C., USA
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  • Lawrence F. Johnson
    Affiliations
    From the Division of Surgery, Walter Reed Army Institute of Research Washington, D. C., USA

    From the Department of Surgery, Medicine, and Clinical Investigation, Walter Reed Army Medical Center, Washington, D. C., USA
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  • Author Footnotes
    ∗ Present address: Department of Physiology, University of Maryland School of Dentistry, Baltimore.
DOI:https://doi.org/10.5555/uri:pii:0022214383901063
Evaluation of in vivo measurement of transesophageal electrical resistance as an indicator of early experimental esophageal mucosal injury
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      Abstract

      Experimental esophageal mucosal injury has been characterized by an increase in mucosal permeability to acid and a fall in transmucosal electrical potential difference (PD). We have developed a technique for measuring transesophageal electrical resistance in an in vivo rabbit model of esophageal injury and have performed experiments to assess this parameter as an index of esophageal injury. As expected, tissue resistance varied inversely with mucosal area. The current-voltage plot for the esophagus with or without trypsin, bile, or acid injury remained linear with no “breakpoints.” Tissue resistance was compared with standard indices of mucosal injury such as acid flux, PD, and morphologic change in experimental esophageal injury due to acid, bile, and trypsin. Our results show that tissue resistance is more sensitive than either PD or acid flux in detecting early esophageal injury due to low concentrations of acid or trypsin and, as opposed to PD, always showed a persistent, unidirectional change with injury. Thus these data show that in vivo measurement of transesophageal electrical resistance is a useful technique for assessing esophageal mucosal injury, in that it is the most sensitive indicator of esophageal injury we have observed.

      Abbreviations:

      potential difference ((PD)), taurodeoxycholate ((TDC))
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      Article info

      Publication history

      Accepted: May 24, 1983
      Received: February 22, 1983

      Footnotes

      ☆The opinions or assertions contained herein are those of the authors and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0022214383901063

      Copyright

      © 1983 Published by Elsevier Inc.

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