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Abstract
We used a mixture of low molecular weight polymers of polyethylene glycol (PEG) to
study intestinal permeability in children with chronic diarrhea. After an oral load,
urinary recovery of the longer chain, higher molecular weight polymers was significantly
decreased compared with that in healthy adults and infants without disease of the
gastrointestinal mucosa. A correlation was observed between clinical severity of disease,
histopathologic condition of the small bowel mucosa, and PEG scores. These results
indicate that intestinal permeability in children can be studied by noninvasive means
and that an assessment of mucosal integrity can be obtained.
Abbreviations:
PCD (percent dose recovery), PEG (polyethylene glycol), PEG-M (polyethylene glycol mixture), PEG 400 (polyethylene glycol of a mean molecular weight of 400)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
April 1,
1986
Received:
September 30,
1985
Footnotes
☆Supported in part with federal funds from the USDA/ARS under Cooperative Agreement No. 58-7MNI-6-100.
☆☆The contents of this publication do not necessarily reflect the views or policies of the U.S. Department of Agriculture, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government.
Identification
Copyright
© 1986 Published by Elsevier Inc.
