This paper is only available as a PDF. To read, Please Download here.
We used a mixture of low molecular weight polymers of polyethylene glycol (PEG) to study intestinal permeability in children with chronic diarrhea. After an oral load, urinary recovery of the longer chain, higher molecular weight polymers was significantly decreased compared with that in healthy adults and infants without disease of the gastrointestinal mucosa. A correlation was observed between clinical severity of disease, histopathologic condition of the small bowel mucosa, and PEG scores. These results indicate that intestinal permeability in children can be studied by noninvasive means and that an assessment of mucosal integrity can be obtained.
Abbreviations:PCD (percent dose recovery), PEG (polyethylene glycol), PEG-M (polyethylene glycol mixture), PEG 400 (polyethylene glycol of a mean molecular weight of 400)
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Translational Research
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Intestinal permeability in children with Crohn's disease and coeliac disease.Br Med J. 1982; 285: 20-21
- Abnormal intestinal permeability to sugars in villous atrophy.Lancet. 1979; 2: 1107-1109
- Intestinal permeability assessed by excretion ratios of two molecules: results in coeliac disease.Br Med J. 1978; 2: 1060
- Low-molecular-weight polyethylene glycol as a probe of gastrointestinal permeability after alcohol ingestion.Dig Dis Sci. 1981; 26: 971-975
- Influence of fasting on intestinal permeability and disease activity in patients with rheumatoid arthritis.Scand J Rheumatol. 1982; 11: 33-38
- Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG) 400.Gastroenterology. 1977; 73: 247-251
- Polyethylene glycol polymers of low molecular weight as probes of intestinal permeability. I. Innovations in analysis and quantitation.J Lab Clin Med. 1986; 107: 290-298
- Delayed complete functional lactase sufficiency in breast-fed infants.J Pediatr Gastroenterol Nutr. 1983; 2: 478-482
- Intestinal permeability changes and excretion of micro-organisms in stools of infants with diarrhoea and vomiting.Arch Dis Child. 1985; 60: 326-332
- Intestinal sugar permeability: relationship to diarrhoeal disease and small bowel morphology.J Pediatr Gastroenterol Nutr. 1985; 4: 568-574
- A comparison of acquired monosaccharide intolerance and acute diarrheal syndrome.J Pediatr Gastroenterol Nutr. 1982; 1: 81-89
- Carbohydrate malabsorption in infants with diarrhea studied with the breath hydrogen test.J Pediatr. 1983; 102: 371-375
- Passage of molecules through the wall of the gastrointestinal tract.Gut. 1980; 21: 208-214
- Effect of hyperosmolar stimuli and coeliac disease on the permeability of the human gastrointestinal tract.Clin Sci Mol Med. 1978; 54: 495-501
- Transmucosal passage of inert molecules in health and disease.in: Skadhauge E Heintze K Intestinal absorption and secretion. MTP Press, London1983: 527
- Intestinal surface area in infants with acquired monosaccharide intolerance.J Pediatr. 1978; 92: 566-571
- Passage of molecules through the wall of the gastrointestinal tract. Urinary recovery of different-sized polyethylene glycols after intravenous and intestinal deposition.Scand J Gastroenterol. 1984; 19: 315-320
- Intestinal permeability: an editorial review.J Pediatr Gastroenterol Nutr. 1985; 4: 520-522
Accepted: April 1, 1986
Received: September 30, 1985
☆Supported in part with federal funds from the USDA/ARS under Cooperative Agreement No. 58-7MNI-6-100.
☆☆The contents of this publication do not necessarily reflect the views or policies of the U.S. Department of Agriculture, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government.
© 1986 Published by Elsevier Inc.