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Abstract
To establish whether a relationship exists between cutaneous and bronchial reactivity
to leukotriene D4 (LTD4), endpoint cutaneous reactivity and bronchial reactivity were determined in six patients
with asthma, six patients with seasonal allergic rhinitis, and six nonatopic men.
In all subjects, increasing doses of LTD4 produced decreases in specific airway conductance (SGaw) and flow at 30% of vital
capacity measured from a partial forced expiratory maneuver (V30P). Intracutaneous
injections of LTD4 and histamine resulted in immediate wheal and erythema reactions in all patients.
Serial 10-fold dilutions of LTD4 and histamine were injected to establish the lowest dose capable of producing a 4
mm wheal with erythema. Endpoint cutaneous reactivity to LTD4 ranged from 1 μmol to 100 pmol in controls and from 100 nmol to 1 fmol in patients
with asthma, but statistically significant differences between groups were not apparent
even with inclusion of six additional subjects. No meaningful correlations were found
between the quantity of LTD4 producing the threshold cutaneous reaction and the dose of inhaled LTD4 that produced a 35% decrease in SGaw and 30% decrease in V30P. In contrast to the
bronchi, where subjects in all three groups were 264 to 840 times more sensitive to
LTD4 than to methacholine, ![Math Eq]()
subjects (![Math Eq]()
with asthma) were less sensitive to LTD4 than to histamine in terms of endpoint cutaneous reactivity. However, seven of 18
subjects who were more sensitive to LTD4 than to histamine had relative potencies ranging from 5 to 500,000.
subjects (
with asthma) were less sensitive to LTD4 than to histamine in terms of endpoint cutaneous reactivity. However, seven of 18
subjects who were more sensitive to LTD4 than to histamine had relative potencies ranging from 5 to 500,000.Abbreviations:
LTD4 (leukotriene D4), SGaw (specific airway conductance), V30P (flow at 30% of vital capacity measured from a partial forced expiratory maneuver)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
April 8,
1986
Received:
December 11,
1985
Footnotes
☆Supported by Public Health Service Grants AI-11403 and RR-00048, the Ernest S. Bazley Foundation, the Chicago Community Trust, and the Clinical Research Center, Northwestern Memorial Hospital.
Identification
Copyright
© 1986 Published by Elsevier Inc.
