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Abstract
The determination of γ-seminoprotein (γ-Sm) (also called prostate-specific antigen
[PSA], prostate antigen [PA], or p30) in human serum has been recently demonstrated
to be more sensitive and specific for diagnosing prostate cancer and monitoring the
condition of patients with prostate cancer than the prostatic acid phosphatase (PAP)
test. Because the -γ-Sm (PSA) test seems likely to replace the PAP test in the area
of urology and study of prostate-specific antigens is expanding, we have reviewed
physicochemical properties and clinical significance of two prostate-specific antigens,
γ-Sm (PSA) and β-microseminoprotein (β-MSP). Both proteins have been proved to originate
in the prostate gland and have not been detected in any other human tissues by an
immunohistologic study. The usefulness of -γ-Sm and β-MSP in determining the origin
of metastatic tumors has also been shown. γ-Sm is a glycoprotein with a molecular
weight of 26,079 for the peptide portion, of which the amino acid sequence is identical
to so-called PSA and homologous with serine proteases (the kallikrein family). its
chymotrypsin-like activity with a unique substrate specificity has also been demonstrated.
The molecular weight of β-MSP is 10,652 from the amino acid sequence, in which the
protein has been shown to contain no alanine residue.
Abbreviations:
CA (carbohydrate antigen), HMW-SV-protein (high molecular weight protein secreted from seminal vesicle), β-MSP (β-microseminoprotein), PA (prostate antigen), PAP (prostatic acid phosphatase), PSA (prostate-specific antigen), γ-SM (γ-seminoprotein), TSA (tumor-specific antigen)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
January 24,
1989
Received in revised form:
December 28,
1988
Received:
October 11,
1988
Identification
Copyright
© 1989 Published by Elsevier Inc.