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Abstract
The combination of a transcutaneous microdialysis probe and continuous flow analysis
was tested for continuous glucose monitoring in eight newborn infants who were fed
intravenously. The probe was placed on the skin, which was first stripped with cellophane
tape to increase the skin permeability. The skin was stripped until the transepidermal
water loss reached values greater than 80 gm/m2/hr. Dialysate concentrations were monitored for 165 minutes while the blood glucose
concentrations were manipulated by changing the infusion rate of glucose. Blood glucose
concentration was linearly related to the dialysate concentration. Because the dialysate/blood
glucose ratio varied among the infants, the dialysate concentration was calibrated
to estimated blood values with a single-point and a multiple-point calibration method.
The latter method yielded more accurate estimates of the blood values. We conclude
that transcutaneous microdialysis may be used for glucose monitoring in newborn infants.
Abbreviations:
CV (coefficient of variation), EDTA (ethyleredieminetetraacetic acid), NADP (nicotinemide-adenine denucleotide phosphate), SD (standard deviation), TEWL (transepidermal water loss), TRIS (tris(hydroxymethyl)aminomethane)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
February 18,
1994
Received in revised form:
December 8,
1993
Received:
April 19,
1993
Footnotes
☆Supported by grant GGN88.1574 of the Dutch Technology Foundation.
Identification
Copyright
© 1994 Published by Elsevier Inc.
