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Original article| Volume 124, ISSUE 2, P255-262, August 1994

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Soluble CD antigen (cytokine) expression in various hyperthyroid states and use in the assessment of propylthiouracil treatment

  • Edward Dennis Murphy
    Correspondence
    Reprint requests: E. Dennis Murphy, MD, 530 Winnetka Ave., Winnetka, IL 60093.
    Affiliations
    From the Department of Medicine, The Evanston Hospital Evanston, Illinois USA

    Northwestern University Medical School Chicago, Illinois USA
    Search for articles by this author
  • Pat Kallio
    Affiliations
    From the Department of Medicine, The Evanston Hospital Evanston, Illinois USA

    Northwestern University Medical School Chicago, Illinois USA
    Search for articles by this author
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      Abstract

      The soluble CD antigens sCD8, sCD23, and sCD25 are increased in untreated Graves' hyperthyroidism. These levels remain elevated when euthyroidism is established in response to propylthiouracil (PTU) therapy but decrease to control values after PTU treatment is discontinued, when euthyroldlsm has been established and maintained. Neither sCD8 nor sCD23 are elevated in patients with euthyroid Graves' ophthalmopcrthy nor in the hyperthyroid phase of subacute thyroidltis. sCD25 is increased to an intermediate degree in these disorders. Soluble CD8 ≥ 450 U/ml is sensitive, specific, and predictive of PTU success as sole therapy or need for definitive therapy in untreated and PTU-treated Graves' hyperthyroidism, exceeding the predictive values of thyroid-stimulating hormone receptor antibody, thyroid peroxidase antibody, and T3 radioimmunoassay.

      Abbreviations:

      IL-2R (interleukin-2R), PTU (propylthiouracil), RAI (radioactive iodine), RIA (radioimmunoassay), sCD (soluble cluster of differentiation), TPO (thyroid peroxidase), TSH (thyroid-stimulating hormone), TSHrAb (TSH receptor antibody)
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