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- 1.1. A description is given of a method for terminal infiltration of local anesthetic solutions by dermal wheals on guinea pigs.
- 2.2. The results obtained by this method are affected by the following factors:
- 2.1.a. Age and weight of pig.
- 2.2.b. Amount of local anesthetic.
- 2.3.c. Type of local anesthetic.
- 2.4.d. Fatigue.
- 3.3. The method gives results which correspond closely to those obtained by the dermal wheal method on man.
- 4.4. It is accurate to within less than 10 per cent difference in concentration of local anesthetic solution.
- 5.5. It is more sensitive than the rabbit's cornea method.
- 6.6. It is believed that the rabbit's cornea method, and the guinea pig method together, give results which constitute a reliable index of the value of a local anesthetic.
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- J. Lab. & Clin. Med. 1925; 11: 139-162
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Received: September 20, 1929
© 1929 Published by Elsevier Inc.