The fungicidal power of phenol derivatives: II. Strength in the presence of proteins

The fungicidal power of phenol derivatives

II. Strength in the presence of proteins

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1.
1. Three phenol derivatives have been compared with iodine and four other drugs of common clinical usage in the presence of blood serum, vesicle fluid, and hide powder.
2.
2. The fungicidal power of iodine as determined in water and broth suspensions was greatly reduced in suspensions of serum, vesicle fluid, and hide powder; that of n-hexyl resorcinol was reduced but the relative diminution was less than that of iodine; saturated solutions of chlorothymol failed to kill in the presence of proteins while thymol was effective only in the presence of hide powder; benzoic acid, salicylic acid and sodium thiosulphate were entirely ineffective in the protein suspensions, but sodium hypochlorite maintained its killing power in high concentrations.
3.
3. Higher phenols have been found worthy of further clinical study in the treatment of fungus diseases.
4.
4. A drug more specific in its action than those now available is needed.

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- Woodward G.J.
- Kingery L.B.
- Williams R.J.
The Fungicidal Power of Phenol Derivatives. I. Effect of Introducing Alkyl Groups and Halogens.
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Received: October 12, 1934

With Lyle B. Kingery, M.D. and Roger J. Williams, Ph.D., D.Sc.

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