Research Article| Volume 20, ISSUE 9, P950-953, June 1935

The fungicidal power of phenol derivatives

II. Strength in the presence of proteins
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      • 1.
        1. Three phenol derivatives have been compared with iodine and four other drugs of common clinical usage in the presence of blood serum, vesicle fluid, and hide powder.
      • 2.
        2. The fungicidal power of iodine as determined in water and broth suspensions was greatly reduced in suspensions of serum, vesicle fluid, and hide powder; that of n-hexyl resorcinol was reduced but the relative diminution was less than that of iodine; saturated solutions of chlorothymol failed to kill in the presence of proteins while thymol was effective only in the presence of hide powder; benzoic acid, salicylic acid and sodium thiosulphate were entirely ineffective in the protein suspensions, but sodium hypochlorite maintained its killing power in high concentrations.
      • 3.
        3. Higher phenols have been found worthy of further clinical study in the treatment of fungus diseases.
      • 4.
        4. A drug more specific in its action than those now available is needed.
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