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Rapid Communication| Volume 22, ISSUE 10, P991-997, July 1937

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The rôle of vitamin B1 in cardiovascular diseases

Preliminary report
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      Abstract

      Clinically, these patients were easier to manage, were contented, and used less medication than any group we have had under our supervision at this Facility. With the exception of three patients, all stated that they felt better than they had in years. No controls were used in this series, as our number of patients was rather limited. A new series is being started in which there will be controls. It is realized that we have not exhausted all the means of determining whether these patients have improved clinically, but the following report reveals that the patients have improved. Respiration average for the first week, of the 30 patients, was 21, the average for the last week under treatment was Math Eq. Pulse rate average for the first week was 89, the last week 79. Blood pressure showed definite improvement, with exception of one case, and the blood pressure gradually increased in this one instance. Patients had electrocardiograms before and after treatment, but changes were inconstant and no definite conclusion could be derived from them. The patients were walking from two to four miles per day at the time of discharge from this hospital, and reported no undue ill effects. This is definitely better than any group we have had under our supervision. It will be noted that their respiration and pulse rates and blood pressure showed improvement over admission to this hospital after indulging in exercise. Whether this improvement is entirely due to vitamin B1 therapy or not we are unable to say. There were no deaths in this series of cases, and the average length of hospitalization was 114 days.
      Thirteen of eighteen cardiac patients showed an abnormal vitamin C metabolism, indicated by the low urinary excretion of cevitamic acid following twelve to fourteen days' saturation with 500 mg. of a daily ingestion of cevitamic acid given in form of four glasses of orange juice daily.
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