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In ten individuals without thyroid disease and maintained on a low iodine diet; with normal metabolic rates and normal whole blood iodine averaging 4.0 μg per cent, the average serum iodine was 7.1 μg per cent. The serum iodine constituted, on an average, 95 per cent of the total blood iodine.
In ten patients with exophthalmic goiter, with an average basal metabolic rate of plus 60 per cent, and maintained on a low iodine intake, the average blood iodine was 10.0 μg per cent, the average serum iodine was 18.0 μg per cent. On an average, 95 per cent of the iodine of the blood was in the serum.
Following lipiodolization of ten patients without thyroid disease, the whole blood iodine ranged from 18.5 to 3153.0 μg per cent, with the serum iodine fluctuating from 25.7 to 4,232.0. From 61 to 88 per cent, or on an average 75 per cent, of the total iodine of the blood was in the serum.
In ten patients with exophthalmic goiter, with an average basal metabolic rate of plus 35 per cent, while receiving Lugol's solution or potassium iodide by mouth, the blood iodine concentration fluctuated from 15.2 to 107.0 μg per cent, with the serum iodine concentration varying from 20.2 to 130.0. From 60 to 80 per cent, or at an average 72 per cent, of the iodine of the blood was in the serum.
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Received: February 28, 1940
☆This investigation was aided by a grant from the Comly Fund for Research of the Ohio State University.
© 1940 Published by Elsevier Inc.