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Research Article| Volume 26, ISSUE 1, P52-64, October 1940

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The role of blood clotting anomalies in the hemorrhagic diseases

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      Abstract

      Prolongation of clotting time may contribute to those hemorrhagic states in which we can demonstrate (or postulate) either prothrombin or thromboplastin deficiencies or an excess of antithrombic factors. Calcium may be excluded from practical consideration. Factors such as fibrinogen and platelet defects play a role in determining the effectiveness of clotting and thrombosis in the arrest of hemorrhage. All these are controlling mechanisms, and the prior causative factors, including capillary injury, must also receive the fullest consideration.
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