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Abstract
In summary, the following points may be accepted as a tentative working basis for
present therapeutic applications, and for further exploratory excursions into this
absorbing and important phase of medicine: (1) the reticuloendothelial system represents
a functional unit arising from mesenchymal derivatives possessing a common phagocytic
capacity; (2) certain morphologic variations associated with a variety of physiologic
functional requirements may be recognized; (3) under pathologic conditions and in
tissue culture such morphologic criteria may become either accentuated or diminished;
(4) when highly stimulated, all phagocytic cells, regardless of the ease of differential
identification under physiologic conditions, tend to assume a common appearance and
may be designated by the common descriptive term, macrophage; (5) while originally
protective and conservational in functional objectives in the normal body economy,
these phagocytic scavengers of the mammalian tissues may assume an excessive selective
destructive affinity for any of the normal blood elements, thus precipitating a variety
of characteristic clinical syndromes; (6) the spleen is usually the site of the greatest
destructive activity, and when the appropriate diagnostic tests have localized the
major pathology to this organ, splenectomy is indicated as the rational therapeutic
procedure; (7) conclusive evidence of the active participation of the reticuloendothelial
cells in humoral antibody production would now seem to have been obtained; (8) this
reaction has both favorable (protective antibodies) and unfavorable (hemolysin production)
implications for mammalian survival; (9) a constantly increasing accumulation of carefully
controlled factual information is providing an ever broader and more substantial foundation
for a more effective manipulation of this important defense unit in the interest of
individual health.
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© 1940 Published by Elsevier Inc.
