Research Article| Volume 26, ISSUE 1, P190-198, October 1940

Clinical studies of the organic acid-soluble phosphorus of red blood cells in different acidotic states

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      The concentration of organic acid-soluble phosphorus in the blood cells is greatly reduced during severe acidosis in subjects with adequate renal function, following the ingestion of ammonium chloride, in diabetic coma, and in infants with profuse diarrhea. The decrease is in the diphosphoglycerate fraction, which appears to be one source of the increased phosphaturia that occurs in these conditions. High, normal, or low concentrations of organic acid-soluble phosphorus in the blood cells may be found during acidosis in nephritic subjects with low renal function, depending upon different conditions present in individual cases. The changes of phosphorus distribution are closely related to the state of other electrolytes in the blood, and they appear to constitute a valuable index of the functional state of the labile phosphorus reserves of the body.
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