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Research Article| Volume 26, ISSUE 1, P190-198, October 1940

Clinical studies of the organic acid-soluble phosphorus of red blood cells in different acidotic states

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      Abstract

      The concentration of organic acid-soluble phosphorus in the blood cells is greatly reduced during severe acidosis in subjects with adequate renal function, following the ingestion of ammonium chloride, in diabetic coma, and in infants with profuse diarrhea. The decrease is in the diphosphoglycerate fraction, which appears to be one source of the increased phosphaturia that occurs in these conditions. High, normal, or low concentrations of organic acid-soluble phosphorus in the blood cells may be found during acidosis in nephritic subjects with low renal function, depending upon different conditions present in individual cases. The changes of phosphorus distribution are closely related to the state of other electrolytes in the blood, and they appear to constitute a valuable index of the functional state of the labile phosphorus reserves of the body.
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      References

        • Forbes E.B.
        • Keith M.H.
        A Review of the Literature of Phosphorus Compounds in Animal Metabolism.
        Wooster, Ohio, Technical Series, Bull. 5. 1914; : 510
        • Fitz R.
        • Alsberg C.L.
        • Henderson L.J.
        Concerning the Excretion of Phosphoric Acid During Experimental Acidosis in Rabbits.
        Am. J. Physiol. 1907; 18: 113
        • Henderson L.J.
        A Critical Study of the Process of Acid Excretion.
        J. Biol. Chem. 1911; 9: 403
        • Haldane J.B.S.
        • Wigglesworth V.B.
        • Woodrow C.E.
        The Effect of Reaction Changes on Human Inorganic Metabolism.
        in: Proc. Roy. Soc., London, s. B. 96. 1924–1925: 1
        • Byrom F.B.
        Blood Phosphorus in Health and Disease. IV. Phosphorus Content of the Blood in Diabetes Mellitus.
        Brit. J. Exper. Path. 1929; 10: 10
        • Rapoport S.
        Ueber Phosphorglycerinsäure als Transportsubstanz des Blutphosphors und ihr Verhalten bei Experimenteller Ammonchloridazidose.
        Biochem. Ztschr. 1937; 289: 411
        • Rapoport S.
        Ueber Phosphorglycerinsäure als Transportsubstanz des Blutphosphors und ihr Verhalten bei Experimenteller Ammonchloridazidose.
        Biochem. Ztschr. 1937; 289: 416
        • Guest G.M.
        • Rapoport S.
        Role of Acid-Soluble Phosphorus Compounds in Red Blood Cells in Experimental Rickets, Renal Insufficiency, Pyloric Obstruction, Gastroenteritis, Ammonium Chloride Acidosis and Diabetic Acidosis.
        Am. J. Dis. Child. 1939; 58: 1072
        • Marriott W.McK.
        • Howland J.
        Phosphate Retention as a Factor in the Production of Acidosis in Nephritis.
        Arch. Int. Med. 1916; 18: 708
        • Byrom F.B.
        • Kay H.D.
        Blood Phosphorus in Health and Disease. II. Changes in the Phosphorus Compounds of the Blood in Renal Disease.
        Brit. J. Exper. Path. 1927; 8: 429
        • Ashley A.
        • Guest G.M.
        Distribution of Blood Phosphorus After Suppression of Renal Function.
        J. Clin. Investigation. 1934; 13: 219
        • Guest G.M.
        • Rapoport S.
        Studies of Diphosphoglyceric Acid in Blood Cells.
        in: Proc. Am. Soc. Biol. Chem. J. Biol. Chem. 123. 1938: xlvii
        • Rapoport S.
        • Guest G.M.
        Role of Diphosphoglyceric Acid in the Electrolyte Equilibrium of Blood Cells: Studies of Pyloric Obstruction in Dogs.
        J. Biol. Chem. 1939; 131: 675
        • Chabanier H.
        • Lobo-Onell C.
        Exploration fonctionelle des reins.
        in: Masson et Cie., Acidose et urémie, Paris1930: 505
        • Chabanier H.
        • Guillaumin C.O.
        • Laudat M.
        • Lévy M.
        • Paget M.
        • Vaille C.
        À propos du chlore sanguin.
        Bull. Soc. chim. biol. 1937; 19: 800
        • Lévy M.
        L'acidose et l'insuffisance rénale aiguë chez le nourrisson.
        Masson et Cie, Paris1932
        • Ribadeau-Dumas L.
        • Lévy M.
        • Mignon S.
        Études sur les chlorémies plasmatique et globulaire du nourrisson.
        Rev. franç. de pédiat. 1937; 13: 1
        • Gamble J.L.
        Extracellular Fluid.
        Bull. Johns Hopkins Hosp. 1937; 61: 151
        • Hamilton B.
        • Kajdi L.
        • Meeker D.
        The Acidosis of Acute Diarrhea in Infancy.
        Am. J. Dis. Child. 1929; 38: 314
        • Guest G.M.
        • Andrus W.De W.
        Chemical Studies of the Blood in High Intestinal Obstruction. I. Distribution of Phosphorus and Intracellular Changes.
        J. Clin. Investigation. 1932; 11: 455
        • Guest G.M.
        • Rapoport S.
        Role of Diphosphoglycerate and Other Organic Acid-Soluble Phosphorus Compounds of the Red Blood Cells in the Electrolyte Equilibrium of the Blood.
        in: Am. Assoc. for Advancement of Science, Symposium, Blood, Heart, and Circulation. Science Press, Washington, D. C.,1940: 55
        • Rapoport S.
        • Guest G.M.
        Decomposition of Diphosphoglycerate in Acidified Blood: Its Relationship to Reactions of the Glycolytic Cycle.
        J. Biol. Chem. 1939; 129: 781