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Abbreviations:
CI (combination index for quantifying synergism additive effect antagonism), DRI (dose-reduction index), MEP (median-effect principle plot), Isobol (isobologram for equi-effect graphics for two drug doses)To read this article in full you will need to make a payment
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References
- Analysis of combined drug effects: a new look at a very old problem.Trends Pharmacol Sci. 1983; 4: 450-454
- The median-effect principle and the combination index for quantitation of synergism and antagonism.in: Chou T-C Rideout D Synergism and antagonism in chemotherapy. Academic Press, San Diego1991: 61-102
- Encyclopedia of human biology. vol 2. Academic Press, San Diego1997: 675-683 Chemotherapeutic synergism, potentiation and antagonism. 2nd ed.
- Computerized quantitation of synergism and antagonism of taxol, topotecan and cisplatin against teratocarcinoma cell growth: a rational approach to clinical protocol design.J Natl Cancer Inst. 1994; 86: 1517-1524
- Encyclopedia of cancer. vol 1. Academic Press, San Diego1997: 368-379 Chemotherapy: synergism and antagonism. 2nd ed.
- Inhibition of 11-β hydroxysteroid dehydrogenase by bioflavonoids and their interaction with furosemide and gossypol.J Lab Clin Med. 1998; 131: 32-38
- Permuterm Subject Index, Science Citation Index. Institute for Scientific Information, Philadelphia1997
- The employment of combinations of drugs in the chemotherapy of neoplasia: a review.Cancer Res. 1957; 17: 635-654
- What is synergy?.Pharmacol Rev. 1989; 41: 93-141
- Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.Adv Enzyme Regul. 1984; 22: 27-55
- Relationships between inhibition constants and fractional inhibitions in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types of mechanisms of inhibition.Mol Pharmacol. 1974; 10: 235-247
- Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands.J Theor Biol. 1996; 39: 253-276
- Generalized equations for the analysis of inhibitors of Michaelis-Menten and higher order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors.Eur J Biochem. 1981; 115: 207-216
- Applications of the median-effect principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents.in: Harrap KR Connors TA New Avenues of developmental cancer chemotherapy. 2nd ed. Bristol-Myers Symposium series. Academic Press, New York1987: 37-64
- Dose-effect analysis with microcomputers: quantitation of ED50, LD50, synergism, antagonism, low-dose risk, receptor-ligand binding and enzyme kinetics.in: Manual and software. Biosoft, Cambridge, England1987
- CalcuSyn for Windows, multiple-drug dose-effect analyzer and manual.Biosoft, Cambridge, England1996
- Antagonism and antagonist.Pharmacol Rev. 1957; 9: 237-242
- Synergy, additivism and antagonism in immunosupression: a critical review.Clin Exp Immunol. 1977; 28: 1-18
- Enzyme metabolic inhibitors. vol 1. Academic Press, New York1963: 55-79 2nd ed.
- Science Citation Index. Institute for Scientific Information, Philadelphia1998 (1983–1998)
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