Pulmonary hypertension and inflammation

References

1. • Voelkel NF
   • Tuder RM
   • Weir EK
   Pathophysiology of primary pulmonary hypertension: from physiology to molecular mechanisms.
   in: Rubin LJ Rich S Primary pulmonary hypertension. Marcel Dekker, New York1997: 83-129
   • Google Scholar
2. • Lee S-L
   • Wang WW
   • Lanzillo JJ
   • Fanburg BL
   Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture.
   Am J Physiol. 1994; 266: L46-L52
   • Google Scholar
3. • Voelkel NF
   • Tuder RM
   Cellular and molecular mechanisms in the pathogenesis of severe pulmonary hypertension.
   Eur Respir J. 1995; 8: 2129-2138
   • Google Scholar
4. • Fanburg BL
   • Lee S-L
   A new role for an old molecule: serotonin as a mitogen.
   Am J Physiol. 1997; 272: L795-L806
   • Google Scholar
5. • Heath D
   • Yacoub M
   Lung mast cells in plexogenic pulmonary arteriopathy.
   J Clin Pathol. 1991; 44: 1003-1006
   • Google Scholar
6. • Blair RJ
   • Meng H
   • Marchese MJ
   • Ren S
   • Schwartz LB
   • Tommesen MG
   • et al.
   Human mast cells stimulate vascular tube formation.
   J Clin Invest. 1997; 99: 2691-2700
   • Google Scholar
7. • Caslin AW
   • Heath D
   • Madden B
   • Yacoub M
   • Gosney JR
   • Smith P
   • et al.
   The histopathology of 36 cases of plexogenic pulmonary arteriopathy.
   Histopathology. 1990; 16: 9-19
   • Google Scholar
8. • Tuder RM
   • Groves B
   • Badesch DB
   • Voelkel NF
   Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.
   Am J Pathol. 1994; 144: 275-285
   • Google Scholar
9. • Cool CD
   • Kennedy D
   • Voelkel NF
   • Tuder RM
   Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection.
   Hum Pathol. 1997; 28: 434-442
   • Google Scholar
10. • Kuwara K
    • Ogawa S
    • Matsumoto M
    • Koga S
    • Clauss M
    • Pinsky DJ
    • et al.
    Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells.
    Med Sci. 1995; 92: 4606-4610
    • Google Scholar
11. • Ross R
    The pathogenesis of atherosclerosis: a perspective for the 1990s.
    Nature. 1993; 362: 801-809
    • Google Scholar
12. • Botney MD
    • Bahadori L
    • Gold LI
    Vascular remodeling in primary pulmonary hypertension.
    Am J Pathol. 1994; 114: 286-295
    • Google Scholar
13. • Pertovaara L
    • Kaipainen A
    • Mustonen T
    • Orpana A
    • Ferrara N
    • Saksela O
    • et al.
    Vascular endothelial growth factor is induced in response to transforming growth factor-α in fibroblastic and epithelial cells.
    J Biol Chem. 1994; 269: 6271-6274
    • Google Scholar
14. • Humbert M
    • Monti G
    • Brenot F
    • Sitbon O
    • Portier A
    • Grangeot-Keros L
    • et al.
    Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.
    Am J Respir Crit Care Med. 1995; 151: 1628-1631
    • Google Scholar
15. • Stavri GT
    • Hong Y
    • Zachary IC
    • Breier G
    • Baskerville PA
    • Yla-Herttuala S
    • et al.
    Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells.
    FEBS Lett. 1995; 358: 311-315
    • Google Scholar
16. • Tuder RM
    • Wang J
    • Lee SD
    • Voelkel NF
    Vascular endothelial growth factor (VEGF) expression in normal and remodeled pulmonary arteries in severe pulmonary hypertension.
    Am J Respir Crit Care Med. 1997; 155 ([abstract]): A627
    • Google Scholar
17. • Barleon B
    • Sozzani S
    • Zhou D
    • Weich HA
    • Mantovani A
    • Marmé D
    Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1.
    Blood. 1996; 87: 3336-3343
    • Google Scholar
18. • MacDermot J
    • Kelsey CR
    • Waddell KA
    • Richmond R
    • Knight RK
    • Cole PT
    • et al.
    Synthesis of leukotriene B4 and prostaniods by human alveolar macrophages: Analysis by gas chromatography/mass spectrophotometry.
    Prostaglandins. 1984; 27: 163-177
    • Google Scholar
19. • Lepley RA
    • Fitzpatrick FA
    5-lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.
    J Biol Chem. 1994; 269: 24163-24168
    • Google Scholar
20. • Wright L
    • Tuder RM
    • Wang J
    • Cool CD
    • Lepley RA
    • Voelkel NF
    • et al.
    5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension.
    Am J Respir Crit Care Med. 1998; 157: 219-229
    • Google Scholar
21. • Wilson DW
    • Segall HJ
    • Pan LC
    • Dunston SK
    Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats.
    Microvasc Res. 1989; 38: 57-80
    • Google Scholar
22. • Hu L-M
    • Jones R
    Injury and remodeling of pulmonary veins by high oxygen.
    Am J Pathol. 1989; 134: 253-262
    • Google Scholar
23. • Ono S
    • Voelkel NF
    Inflammation and pulmonary hypertension during hypoxia.
    in: Ueda G Veda G Reeves JT Sekiguchi M High altitude medicine. Shinshu University Press, Matsumoto1992: 347-354
    • Google Scholar
24. • Herget J
    • Palecek F
    • Preclik P
    • Cermakova M
    • Vizek M
    • Petrovicka M
    • et al.
    Pulmonary hypertension induced by repeated pulmonary inflammation in the rat.
    J Appl Physiol. 1981; 51: 755-761
    • Google Scholar
25. • Meyrick B
    • Brigham KL
    Repeated Escherichia coli endotoxin-induced pulmonary inflammation causes chronic pulmonary hypertension in sheep structural and functional changes.
    Lab Invest. 1996; 55: 164-176
    • Google Scholar
26. • Resnick N
    • Collins T
    • Atkinson W
    • Bonthron DT
    • Dewey Jr, CF
    • et al.
    Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.
    in: 2nd ed. Proc Natl Acad Sci USA. 90. 1993: 4593-4595
    • Google Scholar
27. • Das KC
    • Lewis-Molock Y
    • White CW
    Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells.
    Am J Physiol. 1995; 269: L588-L602
    • Google Scholar
28. • Forsythe JA
    • Jiang B-H
    • Iyer NV
    • Agani F
    • Leung SW
    • Koos RD
    • et al.
    Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
    Mol Cell Biol. 1996; 16: 4604-4613
    • Google Scholar
29. • Liu Y
    • Cox SR
    • Morita T
    • Kourembanas S
    Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells: identification of a 5′ enhancer.
    Circ Res. 1995; 77: 638-643
    • Google Scholar

30. Stern DM. Hypoxia, inflammation and clotting. Thomas L Petty Aspen Lung Conference, Fortieth Annual Meeting. Chest (in press).

    • Google Scholar
31. • Voelkel NF
    • Tuder RM
    • Bridges J
    • Arend WP
    Interleukin- 1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline.
    Am J Respir Cell Mol Biol. 1994; 11: 664-675
    • Google Scholar
32. • Raines EW
    • Dower SK
    • Ross R
    Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA.
    Science. 1988; 243: 393-397
    • Google Scholar
33. • Li J
    • Perrella MA
    • Tsal JC
    • Yet SF
    • Hsieh CM
    • Yoshizumi M
    • et al.
    Induction of vascular endothelial growth factor gene expression by interleukin-lβ in rat aortic smooth muscle cells.
    J Biol Chem. 1995; 270: 308-312
    • Google Scholar
34. • Voelkel NF
    • Worthen SW
    • Reeves JT
    • Henson PM
    • Murphy RC
    Nonimmunological production of leukotrienes induced by platelet-activating factor.
    Science. 1982; 218: 286-288
    • Google Scholar
35. • Ono S
    • Westcott JY
    • Voelkel NF
    PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats.
    J Appl Physiol. 1992; 73: 1084-1092
    • Google Scholar
36. • Voelkel NF
    • Tuder RM
    • Wade K
    • Höper M
    • Lepley RA
    • Goulet JL
    • et al.
    Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats.
    J Clin Invest. 1996; 97: 2491-2498
    • Google Scholar
37. • Stenmark KR
    • Morganroth MC
    • Remigo LK
    • Voelkel NF
    • Murphy RC
    • Henson PM
    • et al.
    Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension.
    Am J Physiol. 1985; 248: H859-H866
    • Google Scholar
38. • Tuder RM
    • Flook BE
    • Voelkel NF
    Increased gene expression for VEGF and the VEGF receptors KDR/F1k and Fit in lungs exposed to acute or to chronic hypoxia.
    J Clin Invest. 1995; 95: 1798-1807
    • Google Scholar
39. • Tuder RM
    • Allard I
    • Voelkel NF
    Role of vascular endothelial growth factor in hypoxia and monocrotaline induced pulmonary hypertension.
    Circulation. 1996; 94: 1647
    • Google Scholar
40. • Ziche M
    • Morbidelli L
    • Choudhuri R
    • Zhang H-T
    • Donnini S
    • Granger HJ
    • et al.
    Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.
    J Clin Invest. 1997; 99: 2625-2634
    • Google Scholar
41. • Morrell NW
    • Grieshaber SS
    • Danilov SM
    • Majack RA
    • Stenmark KR
    Developmental regulation of angiotensin converting enzyme and angiotensin type 1 receptor in the rat pulmonary circulation.
    Am J Respir Cell Mol Biol. 1996; 14: 526-537
    • Google Scholar
42. • Morrell NW
    • Morris KG
    • Stenmark KR
    Role of angiotensinconverting enzyme and angiotensin II in development of hypoxic pulmonary hypertension.
    Am J Physiol. 1995; 269: H1186-H1194
    • Google Scholar
43. • Morrell NW
    • Atochina EN
    • Morris KG
    • Danilov SM
    • Stenmark KR
    Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.
    J Clin Invest. 1995; 96: 1823-1833
    • Google Scholar
44. • Levin ER
    Mechanisms of disease: Endothelins.
    N Engl J Med. 1995; 333: 356-363
    • Google Scholar
45. • Miyauchi T
    • Yorikane R
    • Sakai S
    • Sakurai T
    • Okada M
    • Nishikibe M
    • et al.
    Contribution of endogenous endothelin1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.
    Circ Res. 1993; 73: 887-897
    • Google Scholar
46. • Ivy DD
    • Parker TA
    • Ziegler JW
    • Galan HL
    • Kinsella JP
    • Tuder RM
    • et al.
    Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus.
    J Clin Invest. 1997; 99: 1179-1186
    • Google Scholar
47. • Perkett EA
    • Lyons RM
    • Moses HL
    • Brigham KL
    • Meyrick B
    Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension.
    J Clin Invest. 1990; 86: 1459-1464
    • Google Scholar
48. • Badesch DB
    • Lee PD
    • Parks WC
    • Stenmark KR
    Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells.
    Biochem Biophys Res Commun. 1989; 160: 382-387
    • Google Scholar
49. • Widimsky J
    • Riedel M
    • Stanek V
    Central haemodynamics during exercise in patients with restrictive pulmonary disease.
    Bull Eur Physiopath Resp. 1977; 13: 369-379
    • Google Scholar
50. • Andoh Y
    • Shimura S
    • Aikawa T
    • Sasaki H
    • Takishima T
    Perivascular fibrosis of muscular pulmonary arteries in chronic obstructive pulmonary disease.
    Chest. 1992; 102: 1645-1649
    • Google Scholar