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Abstract
Inhibition of 11β-hydroxysteroid dehydrogenase (11β-OHSD) can cause a mineralocorticoid
effect. This enzyme, in guinea pig renal cortex microsomes in vitro, is inhibited
by quercetin, tea polyphenols, furosemide, and gossypol. The dietary polyphenols,
quercetin and tea polyphenols, interact with furosemide to enhance its 11β-OHSD inhibitory
effect. Tea polyphenols added to the effect of gossypol. We conclude that the diet
contains inhibitors of 11β-OHSD that can alter the activity of this enzyme and may
modify the degree of endogenous mineralocorticoid activity.
Abbreviations:
11β-OHSD (11β-Hydroxysteroid dehydrogenase), CI (combination index), IC50 (median inhibitory concentration), NAD (nicotinamide adenine dinucleotide), NADP (nicotinamide adenine dinucleotide phosphate)To read this article in full you will need to make a payment
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References
- Several homozygous mutations in the gene for 11β-Hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess.J Clin Endocrinol Metab. 1995; 80: 3145-3150
- Frey F Funder J Monder C First symposium on 11β-hydroxysteroid dehydrogenase. 2nd ed. Steroids. 59. 1994: 61-172
- Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene.Lancet. 1996; 347: 88-91
- Inhibitory effects of gossypol on corticosteroid 11β-hydroxysteroid dehydrogenase from guinea pig kidney: A possible mechanism for causing hypokalemia.J Steroid Biochem. 1991; 39: 169-176
- Inhibition of 11β-Hydroxysteroid dehydrogenase by gossypol and bioflavonoids.J Lab Clin Med. 1992; 120: 792-797
- Inhibition of 11β-Hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds.J Steroid Biochem. 1994; 49: 81-85
- Grapefruit juice and its flavonoids inhibit 11β-hydroxysteroid dehydrogenase.Clin Pharmacol Ther. 1996; 59: 62-71
- Bumetanide: Potent new “loop” diuretic.Br Med J. 1972; 1: 211-213
- Bumetanide and furosemide: A comparison of dose-response curves in healthy men.Br J Clin Pharmacol. 1978; 5: 243-247
- Electrolyte excretion patterns, intravenous and oral doses of bumetanide compared to furosemide.J Clin Pharmacol. 1981; 21: 599-603
- Gossypol: A potential antifertility agent for males.Ann Rev Pharmacol Toxicol. 1984; 24: 329-360
- Antioxidative effect of polyphenol extract prepared from various Chinese teas.Prev Med. 1992; 21: 520-525
- Dose-effect analysis with microcomputer: Quantitation of ED50, LD50, synergism, antagonism, low-dose risk, receptor-ligand binding and enzyme kinetics.([manual and software]) Biosoft, Cambridge, UK1987
- Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors.Adv Enzyme Regul. 1989; 22: 27-55
- The median-effect principle and the combination index for quantitation of synergism and antagonism.in: Chou TC Rideout D Synergism and antagonism in chemotherapy. Academic Press, San Diego1991: 61-102
- Synergy, additivism, and antagonsim in immunosuppression.Clin Exp Immunol. 1977; 28: 1-18
- Synergistic action of liquorice and cortisone in Addison's and Simmonds's disease.Lancet. 1953; 1: 657-661
- Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age.Lancet. 1987; 21: 821-824
- The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers.J Clin Endocrinol Metab. 1990; 70: 1637-1641
- Inhibition of rat renal 11β-Hydroxysteroid dehydrogenase by steroidal compounds and triterpenoids: Structure/function relationship.Biochem Biophys Acta. 1991; 1075: 206-212
- Possible endogenous regulators of steroid inactivating enzymes and glucocorticoid-induced Na+ retention.Steroids. 1994; 59: 352-356
- Bile acids and their amidates inhibit 11β-Hydroxysteroid dehydrogenase obtained from rat kidney.Pflugers Arch (Eur J Physiol). 1991; 418: 538-543
- 11β-Hydroxysteroid dehydrogenase activity (E. C. 1. 1. 1. 146) in human placenta and decidua.J Steroid Biochem. 1980; 13: 1081-1087
- Detection of glycyrrhetinic acid-like factors (GALFs) in human urine.Hypertension. 1992; 20: 356-360
Lee LS, Reidenberg MM. A method for measuring naringenin in biological fluids and its disposition from grapefruit juice by man. Pharmacology. In press.
- Reduced risk of esophageal cancer associated with green tea consumption.J Natl Cancer Inst. 1994; 86: 855-858
- Flavonoids in the human diet.in: Cody C Middleton Jr, E Harborne JB Plant flavonoids in the human diet. Alan R Liss, New York1996: 125-190
- Identification of 6′,7′-dihydroxybeigamottin, a cytochrome P450 inhibitor in grapefruit juice.Drug Metab Dispos. 1996; 24: 1287-1290
- Differences in serum potassium concentrations in normal men in different geographic locations.Clin Chem. 1993; 39: 72-75
- Serum potassium: Values in normal men in Shanghai vs those in men from Shanghai living abroad.Clin Chem. 1994; 40: 340
Article info
Publication history
Accepted:
February 2,
1998
Received in revised form:
January 29,
1998
Received:
November 5,
1996
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Copyright
© 1998 Published by Elsevier Inc.
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