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Abstract
Several lines of evidence suggest that carotenoids may have a beneficial effect on
health as a result of their antioxidant properties. In addition to β-carotene, five
other carotenoids are recovered in noticeable amounts from human plasma and tissues.
Although the effect of β-carotene on in vivo lipid peroxidation has been documented,
few data are available on the effects of the other carotenoids. We evaluated the ability
of the main human carotenoids to reduce lipid peroxidation by determining the correlations
between plasma carotenoid concentration and plasma antioxidant capacity (in 79 healthy
volunteers) and between carotenoid status and breath pentane excretion (in a subgroup
of 24 subjects). Carotenoid intake was assessed by means of a 3-day food recall. Carotenoid
status was evaluated by measurement of β-carotene, lycopene, lutein/zeaxanthin, and
α-carotene in plasma and buccal mucosal cells. Antioxidant status was evaluated by
measurement of the total antioxidant capacity of the plasma. Oxidative stress status
was evaluated by breath pentane measurements. Food recall data and the carotenoid
concentrations in plasma and buccal mucosal cells showed that the subjects had normal
carotenoid intake and normal carotenoid status. The total antioxidant capacity of
the plasma was not related to the concentration of any specific carotenoid. The level
of expired air pentane was not related to the carotenoid status of the subjects. These
results show that normal concentrations of carotenoids in plasma and tissues are not
correlated with these clinical markers of antioxidant and oxidative stress status.
Abbreviations:
ABTS (2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulphonic acid)), ABTS-+ (ABTS radical cation)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
December 12,
1997
Received in revised form:
December 2,
1997
Received:
October 2,
1997
Footnotes
☆Supported by the French Ministry of Research (grant # 94 G 0168 from Aliment-Demain).
Identification
Copyright
© 1998 Published by Elsevier Inc.