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Abstract
In a previous retrospective study, we reported a significant reduction in serum cholesterol
levels following major surgery, and speculated on the possible role of cytokines in
this reduction. The purpose of this article is to report a prospective study of the
association of cytokines with postoperative changes in serum lipoprotein levels. Serum
samples were obtained from 11 male patients before and at intervals for up to 10 days
after surgery, and were assayed for total cholesterol (TC), triglycerides (TG), high-density
lipoprotein cholesterol (HDL-C), cortisol, tumor necrosis factor-α (TNF-α), interleukin-1β
(IL-1β), interleukin-6 (IL-6), and interferon-γ (IFN-γ). LDL-C was calculated. The
TC showed a 27.9% decrease, from a mean of 4.27 mmol/L to 3.08 mmol/L (p < 0.001) after surgery, reaching a nadir at 24 hours and returning to preoperative
values in 7 to 10 days. A similar decrease was noted in the HDL-C and LDL-C levels.
IL-6 levels increased from a mean baseline value of 6 pg/ml to a peak of 143 pg/ml
at 24 hours (p < 0.0006). There was an inverse relationship between TC and IL-6 levels, with r = −0.51 for the entire curve and r = −0.90 for the cholesterol nadir with the IL-6 peak. The other cytokines did not
show significant changes. We conclude that TC and its fractions decrease to a nadir
and that IL-6 increases to a peak approximately 24 hours after major surgery. There
is a significant inverse correlation between TC and IL-6, suggesting a possible role
of IL-6 in postoperative changes in serum lipoproteins.
Abbreviations:
ANCVA (analysis of variance), ApoAl (apolipoprotein Al), ApoB (apolipoprotein B), CI (confidence interval), ELISA (enzyme-linked immunosorbent assay), GM-CSF (granulocyte macrophage-colony stimulating factor), HDL-C (high density lipoprotein cholesterol), IFN-γ (interferon-γ), IL-6 (interleukin-6), IL-1β (interleukin-1β), LCAT (lecithin cholesterol acetyltransferase), LDL-C (low density lipoprotein cholesterol), rhlL-3 (recombinant human interleukin-3), rhM-CSF (recombinant human macrophage colony stimulating factor), TC (total cholesterol), TG (triglycerides), TNF-α (tumor necrosis factor-α), T3 (triiodothyronine), TSH (thyroid stimulating hormone)To read this article in full you will need to make a payment
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References
- The effect of ACTH, cortisone, and operative stress upon blood cholesterol levels.J Lab Clin Med. 1952; 39: 605-617
- Time course for changes of the serum lipoprotein and apolipoprotein T concentrations after major trauma in man.JPEN. 1986; 10: 265-273
- Surgery, not anesthesia, results in postoperative lowering of serum cholesterol levels.Turk J Med Sci. 1993; 17: 123-128
- Changes in serum lipid concentrations during first 24 hours after myocardial infarction.Lancet. 1987; 294: 1588-1589
- Marked decrease in serum HDL cholesterol level during acute myocardial infarction.Acta Med Scand. 1980; 207: 161-166
- Circulating interferon-α levels and hypertriglyceridema in the acquired immunodeficiency syndrome.Am J Med. 1991; 90: 154-162
- Report of the National Cholesterol Education Program Expert Panel on detection evaluation and treatment of high blood cholesterol in adults.Arch Intern Med. 1988; 148: 1-36
- Surgical stress and its effect on serum cholesterol.Surgery. 1967; 61: 221-227
- The acute phase response: from Hippocrates to cytokine biology.in: Bienvenu J Fradelizi D Cytokines and inflammation. John Libbey Eurotext, Paris1991: 3-13
- Interleukin-6 release and the acute-phase reaction in patients with acute myocardial infarction: a pilot study.J Lab Clin Med. 1992; 119: 574-579
- The relationship between the circulating concentrations of interleukin 6 (IL-6), tumor necrosis factor (TNF) and the acute phase response to elective surgery and accidental injury.Lymphokine Res. 1990; 9: 231-238
- Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery.Anesthesiology. 1992; 77: 426-431
- Interferons: From virus inhibitor to modulator of amino acid and lipid metabolism.J Interferon Res. 1987; 7: 591-596
- Serum cholesterollowering activity of granulocyte-macrophage colony-stimulating factor.JAMA. 1988; 260: 3297-3300
- Effects of recombinant human macrophage colony-stimulating factor on plasma cholesterol levels.Blood. 1991; 77: 750-755
- Effects of recombinant human interleukin-3 in patients with relapsed small-cell lung cancer treated with chemotherapy: A dose finding study.J Clin Oncol. 1992; 10: 1131-1140
- Cytokines in pathology and therapy.in: Male D Cytokines and cytokine receptors (in focus). Oxford University Press, Oxford1993: 65-77
- Effects of recombinant human interleukin-6 in cancer patients: A phase I-II study.Blood. 1994; 84: 1434-1441
- Serial fasting lipid profile changes after a single injection of interleukin-6 in normal volunteers.in: 10th International Congress of Endocrinology, San Francisco, USAProgram and Abstracts. Vol 1. June 1996: 346
- Neuroendocrine-immune interactions.N Engl J Med. 1993; 329: 1246-1253
- Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells.Arterioscler Thromb Vasc Biol. 1994; 14: 8-13
- The neuroendocrine response to acute illness: Implications for disease pathogenesis.in: 76th Annual Meeting of the Endocrine Society, Anaheim, CAThe Endocrine Society, Program and Abstracts. June 1994: 167
- Association between serum interleukin-6 and serum 3,5,3-ri-iodothyronine in nonthyroidal illness.J Clin Endocrinol Metab. 1993; 77: 1695-1699
- Inverse correlation between serum interleukin-6 (IL-6) and serum thyroid hormone levels after surgery, and examination of the effect of IL-6 on porcine thyroid follicles.in: 76th Annual Meeting of the Endocrine Society, Anaheim, CAThe Endocrine Society, Program and Abstracts. June, 1994: 293
Article info
Publication history
Accepted:
August 15,
1997
Received:
June 24,
1997
Identification
Copyright
© 1998 Published by Elsevier Inc.
