This study investigates the sex difference of cardiometabolic risk profiles in subjects
with visceral fat obesity (VFO) but normal waist circumference (WC). VFO, which is
defined as visceral adipose tissue (VAT) area more than 100cm2 by computed tomography (CT), and cardiometabolic risk profiles were assessed in 437
subjects with normal WC (197 female subjects and 240 male subjects). The expression
of adiponectin and its receptor in abdominal adipose tissue was measured in a subgroup
of the subjects. Compared with the male subjects, female subjects had a larger abdominal
subcutaneous adipose tissue (SAT) area (158±56 vs 116±38cm2, P<0.01), smaller VAT area (67±44 vs 78±33cm2; P<0.01), and lower prevalence of VFO (12.2 vs 24.2%, P<0.001). This finding was accompanied by upregulated expressions of adiponectin and
its receptor in abdominal adipose tissue in female subjects. Without VFO, the risk
profiles were not significantly different between male subjects and female subjects.
Although risk factors were increased and intensified in both sexes in the presence
of VFO, female subjects with VFO were associated with greater cardiometabolic risks
than male subjects. A regression analysis indicates the ratio of VAT/SAT for female
subjects, whereas VAT and age for male subjects were independently associated with
clustering of multiple cardiometabolic risk factors. In conclusion, in subjects with
normal WC, the prevalence of VFO is lower and the expression of adiponectin and its
receptor is higher in female subjects compared with male subjects. Although VFO was
associated with increased risk in both sexes, the risk profile in female subjects
with VFO was more pronounced.
Abbreviations:
Adipo R1 (adiponectin receptor type 1), BMI (body mass index), CI (confidence interval), CT (computed tomography), DBP (diastolic blood pressure), HDL (high-density lipoprotein), HDL-c (high-density lipoprotein cholesterol), HOMA-IR (homeostatic model assessment index), MRI (magnetic resonance imaging), mRNA (messenger RNA), OR (odds ratio), SAT (subcutaneous adipose tissue), SBP (systolic blood pressure), VAT (visceral adipose tissue), VFO (visceral fat obesity), WC (waist circumference)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: September 14, 2009
Accepted:
August 18,
2009
Received in revised form:
August 16,
2009
Received:
July 8,
2009
Footnotes
Supported by Grants 2006CB503905 and 2006CB503804 for the 973 program and Grant 06G070 from the Army Health Science Foundation.
Identification
Copyright
© 2010 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
