Cardiovascular disease is the leading cause of death and disability in the Western
world. In addition to the advancement of current therapeutic approaches to reduce
the associated morbidity and mortality, regenerative medicine and cell-based therapy
have been areas of continuous investigation. Circulating and bone-marrow-derived stem
or endothelial progenitor cells are an attractive source for regenerative therapy
in the cardiovascular field. In this review, we highlight the advantages and limitations
of this approach with a focus on key observations from animal studies and clinical
trials.
Abbreviations:
BM (bone marrow), CAD (coronary artery disease), CD34 (cluster of differentiation 34), CFU (colony-forming unit), CVD (cardiovascular disease), DM (diabetes mellitus), eNOS (endothelial nitric oxide synthase), EF (ejection fraction), EPC (endothelial progenitor cells), GCSF (granulocyte colony stimulating factor), HSC (hematopoetic stem cell), LV (left ventricular), LVESV (left ventricular end systolic volume), MI (myocardial infarction), MNC (mononuclear stem cell), MRI (magnetic resonance imaging), PB (peripheral blood), LVEDV (left ventricular end diastolic volume), CABG (coronary artery bypass graft surgery), CLI (critical limb ischemia)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: July 20, 2010
Accepted:
June 23,
2010
Received in revised form:
June 23,
2010
Received:
May 10,
2010
Identification
Copyright
© 2010 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
