In this special issue of Translational Research, several articles consider the potential of harnessing stem cells for therapy of
human diseases. This topic is large in a field that is evolving rapidly. Several different
candidate stem cells include embryonic stem cells, induced pluripotent stem cells,
endothelial progenitor cells, and mesenchymal stem cells. Common themes include the
nature and location of endogenous stem cells, preclinical evidence supporting the
potential therapeutic use of stem cells for acute and chronic diseases, the challenges
in translating the preclinical work to clinical applications, as well as the results
of a few randomized clinical trials.
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References
- Bone marrow and circulating stem/progenitor cells for regenerative cardiovascular therapy.Trans Res. 2010; 156: 112-129
- Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.Cell Stem Cell. 2009; 5 (54–3)
- A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.J Am Coll Cardiol. 2009; 54 (2277–6)
- New therapies for the failing heart: trans-genes versus trans-cells.Trans Res. 2010; 156: 130-135
- Stem cell technology for the treatment of acute and chronic renal failure.Trans Res. 2010; 156: 161-168
- Mesenchymal stem cell-derived microvesicles protect against acute tubular injury.J Am Soc Nephrol. 2009; 20: 1053-1067
- Translation of stem cell therapy for neurological diseases.Trans Res. 2010; 156: 155-160
- Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche.Trans Res. 2010; 156: 179-186
- Stem cells and cell therapy approaches in lung biology and diseases.Trans Res. 2010; 156: 187-204
- Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.Proc Natl Acad Sci U S A. 2009; 106: 16357-16362
- Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.Nat Med. 2009; 15: 42-49
- Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.Am J Respir Crit Care Med. 2010;
- Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury.Proc Natl Acad Sci U S A. 2007; 104: 11002-11007
- Endothelial lineage cell as a vehicle for systemic delivery of cancer gene therapy.Trans Res. 2010; 156: 136-146
- Pluripotent stem cell-derived natural killer cells for cancer therapy.Trans Res. 2010; 156: 147-154
- Stem cell approaches for the treatment of type 1 diabetes mellitus.Trans Res. 2010; 156: 169-178
Article info
Publication history
Published online: August 05, 2010
Identification
Copyright
© 2010 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
