Body fat is an important source of adipokines not only in association with energy
balance, but also with inflammatory and immune responses. This study investigated
the relationship between serum levels of adipokines and coronary artery aneurysm in
patients with Kawasaki disease (KD). Levels of leptin, adiponectin, and resistin were
measured in 165 cases, including 4 groups: the control group (n = 85), KD with normal
coronary arteries (n = 41), KD with dilatation and/or ectasia (n = 31), and KD with
coronary aneurysm (n = 8). White blood cells counts (WBC), red blood cells counts
(RBC), hemoglobin (HB), Hematocrit (Hct), platelet count, C reactive protein (CRP),
and erythrocyte sedimentation rate (ESR) were tested in children. Levels of adiponectin
and resistin levels were significantly elevated; hemoglobin significantly decreased
in the group of KD with coronary aneurysm compared with the controls or other KD subgroups.
There were markedly positive relationships between levels of resistin and CRP, and
negative relationships between levels of resistin and RBC in patients with KD. Levels
of adiponectin, resistin, and hemoglobin were associated with the development of coronary
aneurysm in children with KD. The up-regulation of resistin secreted from adipose
tissue may be closely linked to up-regulation of systemic proinflammatory markers
in acute KD.
Abbreviations:
ALT (alanine aminotransferase), AST (aspartate aminotransferase), BSA (body surface area), CALs (coronary artery lesions), CRP (C reactive protein), ESR (erythrocyte sedimentation rate), HB (hemoglobin), Hct (Hematocrit), HMW (high molecular weight), IL (interleukin), IVIG (intravenous immunoglobulin), KD (Kawasaki disease), LMW (low molecular weight), MCP (monocyte chemoattractant protein), MMP (matrix metalloproteinase), RBC (red blood cells counts), TNF (tumor necrosis factor), WBC (white blood cells counts)To read this article in full you will need to make a payment
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References
- Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study.Am J Cardiol. 1982; 49: 1758-1766
- Kawasaki syndrome.Lancet. 2004; 364: 533-544
- Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease.Clin Exp Immunol. 2005; 141: 381-387
- CD25+CD4+ regulatory T cells in patients with Kawasaki disease.J Pediatr. 2004; 145: 385-390
- Adipocytokines: leptin-the classical, resistin-the controversial, adiponectin-the promising, and more to come.Best Pract Res Clin Endocrinol Metab. 2005; 19: 525-546
- Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin.Clin Chem. 2004; 50: 511-525
- The current biology of resistin.J Intern Med. 2004; 255: 439-447
- The evolving role of leptin and adiponectin in chronic liver diseases.Am J Gastroenterol. 2006; 101: 2629-2640
- The emerging role of adipokines as mediators of inflammation and immune responses.Cytokine Growth Factor Rev. 2007; 18: 313-325
- Adipocytokines: mediators linking adipose tissue, inflammation and immunity.Nat Rev Immunol. 2006; 6: 772-783
- Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease.J Am Coll Cardiol. 2008; 52: 1201-1210
Research Committee on Kawasaki Disease 1984 Report of Subcommittee on Standardization of Diagnostic Criteria and Reporting of Coronary Artery Lesions in Kawasaki Disease. Ministry of Health and Welfare, Tokyo, Japan.
- Nationwide survey of Kawasaki disease and acute rheumatic fever.J Pediatr. 1991; 119: 279-282
- Repeated quantitative angiograms in coronary arterial aneurysm in Kawasaki disease.Am J Cardiol. 1985; 56: 846-851
- Increased insulin resistance and serum resistin in Korean patients with Behcet’s disease.Arch Med Res. 2010; 41: 269-274
- Independent association between plasma leptin and C-reactive protein in healthy humans.Circulation. 2004; 109: 2181-2185
- Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS).Circulation. 2001; 104: 3052-3056
- Serum resistin concentrations in children with Kawasaki disease.Inflamm Res. 2010; 59: 915-920
- The serum levels of resistin in rheumatoid arthritis patients.Clin Exp Rheumatol. 2006; 24: 698-701
- Resistin is an inflammatory marker of inflammatory bowel disease in humans.Eur J Gastroenterol Hepatol. 2007; 19: 1070-1074
- Plasma resistin levels in asthmatics as a marker of disease state.J Asthma. 2007; 44: 509-513
- A new infantile acute febrile mucocutaneous lymph node syndrome (MCLS) prevailing in Japan.Pediatrics. 1974; 54: 271-276
- Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome.J Pediatr. 1975; 86: 892-898
- Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.Circulation. 1999; 100: 2473-2476
- Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway.Circulation. 2000; 102: 1296-1301
- Proteolytic cleavage product of 30 kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.Proc Natl Acad Sci USA. 2001; 98: 2005-2010
- Obesity, adiponectin and vascular inflammatory disease.Curr Opin Lipidol. 2003; 14: 561-566
- The potential of adiponectin in driving arthritis.J Immunol. 2006; 176: 4468-4478
- Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus.Kidney Int. 2005; 68: 1825-1833
- Different effects of adiponectin isoforms in human monocytic cells.J Leukoc Biol. 2006; 79: 803-808
- Relationships between human serum resistin, inflammatory markers and insulin resistance.Int J Obes (Lond). 2005; 29: 1315-1320
- Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes.Diabetes Care. 2004; 27: 2450-2457
- Serum resistin is associated with C-reactive protein and LDL cholesterol in type 2 diabetes, coronary artery disease in a Saudi population.Cardiovasc Diabetol. 2005; 4: 10
Article info
Publication history
Published online: February 10, 2012
Accepted:
January 12,
2012
Received in revised form:
January 11,
2012
Received:
October 19,
2011
Footnotes
Conflict of interest: None.
Identification
Copyright
© 2012 Published by Elsevier Inc. All rights reserved.
