In-Depth Review: The Future of Health and Aging Review Article| Volume 163, ISSUE 5, P446-455, May 2014

Infrastructure and resources for an aging population: embracing complexity in translational research

  • Kevin P. High
    Reprint requests: Kevin P. High, Professor of Medicine/Infectious Diseases, Wake Forest School of Medicine, 100 Medical Center Boulevard, Winston-Salem, NC 27157-1042.
    Wake Forest School of Medicine, Winston-Salem, NC
    Search for articles by this author
Published:October 04, 2013DOI:
      The population of the United States and most industrialized nations is undergoing rapid expansion of persons aged 65 years and older. This group experiences more illness, disability, and dependency than young adults and consumes the majority of heath care resources. This demographic change presents a number of challenges to current research infrastructure aimed at translating discoveries to improved human health. Key issues include the need to expand the workforce trained in aging research, development of specific resources and harmonization of measures and outcomes, and a culture change within the scientific community. In particular, complexity must be represented within research design and embraced as an important aspect of review panel critiques.


      AGS (American Geriatrics Society), CTSA (Clinical and Translational Science Award), DWJS (Dennis W. Jahnigen Scholars), EMR (Electronic medical record), GEMSSTAR (Grants for Early Medical and Surgical Specialists in Aging Research), NHP (nonhuman primate), NIA (National Institute on Aging), NIH (National Institutes of Health), OAIC (Older Americans Independence Center), PROMIS (Patient-Reported Outcomes Measurement Information System), RCDC (Research Career Development Cores), SPPB (Short Physical Performance Battery), TFWS (T. Franklin Williams Scholars), VA (Veterans Affairs)
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