There is a clear clinical need for cell therapies to repair or regenerate tissue lost
to disease or trauma. Adipose tissue is a renewable source of stem cells, called adipose-derived
stem cells (ASCs), that release important growth factors for wound healing, modulate
the immune system, decrease inflammation, and home in on injured tissues. Therefore,
ASCs may offer great clinical utility in regenerative therapies for afflictions such
as Parkinson's disease and Alzheimer's disease, spinal cord injury, heart disease,
and rheumatoid arthritis, or for replacing lost tissue from trauma or tumor removal.
This article discusses the regenerative properties of ASCs that can be harnessed for
clinical applications, and explores current and future challenges for ASC clinical
use. Such challenges include knowledge-based deficiencies, hurdles for translating
research to the clinic, and barriers to establishing a new paradigm of medical care.
Clinical experience with ASCs, ASCs as a portion of the heterogeneous stromal cell
population extracted enzymatically from adipose tissue, and stromal vascular fraction
are also described.
Abbreviations:
ASC (adipose-derived stem cell), BMSC (bone marrow-derived stem cell), CAL (cell-assisted lipotransfer), GVHD (graft-versus-host disease), IL (interleukin), SVF (stromal vascular fraction)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 05, 2013
Accepted:
November 18,
2013
Received in revised form:
November 6,
2013
Received:
August 30,
2013
Identification
Copyright
© 2014 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
