Recent efforts to broadly apply genetics to clinical practice have been driven by
the rapid advancement of genomic technologies and the discovery of genes associated
with disease risk, progression, and treatment response. Yet there remain valid concerns
about the complexities and limitations that confront the popular notion of clinical
utility of genetics in personalized medicine. Research is still very much in the mode
of discovery. The excitement of discovery and applications to diagnostics are well
described in each of the articles in this issue. Yet, each article appropriately acknowledges
the limitations that need to be overcome to apply new knowledge to clinical practice.
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References
- Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine.J Proteome Res. 2004; 3: 179-196
American Medical Association and Medco Health Solutions. 59th Annual American society of human genetics conference. 2013.
- The sequence of the human genome.Science. 2001; 291: 1304-1351
- Initial sequencing and analysis of the human genome.Nature. 2001; 409: 860-945
- Translating genetics of CF to personalized medicine.Transl Res. 2015; 168C: 40-49
- ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.Genet Med. 2013; 15: 565-574
- The role of genetic testing in unexplained sudden death.Transl Res. 2015; 168C: 59-73
- Complex genetics of pulmonary disease: lessons from GWAS and next-generation sequencing.Transl Res. 2015; 168C: 22-39
- Finding the missing heritability of complex diseases.Nature. 2009; 461: 747-753
- The case of the missing heritability.Nature. 2008; 456: 18-21
- Gut check: testing the role for the intestinal microbiome in human obesity.Sci Transl Med. 2009; 1: 6-7
- Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children.J Med Microbiol. 2005; 54: 987-991
- CRISPR/Cas9 for genome editing: progress, implications and challenges.Hum Mol Genet. 2014; 23: R40-R46
- A prudent path forward for genomic engineering and germline gene modification.Science. 2015; 348: 36-38
Available at: http://www.PGRN.org. Accessed January 3, 2016.
Available at: http://www.pharmgkb.org/page/cpic. Accessed January 3, 2016.
Food and Drug Administration. Anticipated details of the draft guidance for industry, Food and Drug Administration staff, and clinical laboratories: framework for regulatory oversight of laboratory developed tests (LDTs). 2014. Available at: http://www.fda.gov/downloads/MedicalDevices/ProductsandMedicalProcedures/InVitroDiagnostics/UCM407409.pdf. Accessed January 3, 2016.
Joyner MJ. ‘Moonshot’ medicine will let us down. New York Times. 2015. p A27.
- A new initiative on precision medicine.N Engl J Med. 2015; 372: 793-795
Article info
Publication history
Published online: May 04, 2015
Accepted:
April 22,
2015
Received:
April 21,
2015
Identification
Copyright
© 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
