A disintegrin and metalloprotease 8 (ADAM8) is involved in the tumorigenesis of several
types of solid tumors. However, its exact role in gastric cancer (GC) remains unclear.
The aim of this study was to evaluate the clinical significance of ADAM8 in GC and
to explore its biological effects on gastric carcinogenesis. In this study, quantitative
reverse transcription–polymerase chain reaction, Western blotting, and immunohistochemical
staining analysis revealed that ADAM8 messenger RNA expression was significantly upregulated
in GC tissues compared with noncancerous tissues (P = 0.004), and that positive ADAM8 expression is much more common in tumor tissues
compared with normal tissues (P < 0.001) and is correlated with T stage (P = 0.036), N stage (P = 0.048), vessel invasion (P = 0.002), and a shorter patient overall survival (P = 0.024). In vitro assay indicated that ADAM8 overexpression promoted cell growth
and increased migration and invasion abilities by decreasing the p-p38/p-extracellular
regulated protein kinases (p-ERK) ratio. In conclusion, ADAM8 promotes GC cell proliferation
and invasion, and its expression is positively correlated with poor survival, indicating
that it might be a promising target in GC therapy.
Abbreviations:
ADAM8 (a disintegrin and metalloprotease 8), GC (gastric cancer), OS (overall survival)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: May 12, 2015
Accepted:
May 1,
2015
Received in revised form:
April 29,
2015
Received:
November 5,
2014
Footnotes
Jintuan Huang and Yang Bai contributed equally to this work.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
