Therapeutics targeting the inflammasome after central nervous system injury

  • Juan Pablo de Rivero Vaccari
    Reprint requests: Juan Pablo de Rivero Vaccari, Department of Neurological Surgery, Lois Pope LIFE Center, 1095 NW 14th Terrace, 3-25JJ, Miami, FL 33136-1060
    Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Fla
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  • W. Dalton Dietrich
    Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Fla
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  • Robert W. Keane
    Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Fla

    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Fla
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      Innate immunity is part of the early response of the body to deal with tissue damage and infections. Because of the early nature of the innate immune inflammatory response, this inflammatory reaction represents an attractive option as a therapeutic target. The inflammasome is a component of the innate immune response involved in the activation of caspase 1 and the processing of pro–interleukin 1β. In this article, we discuss the therapeutic potential of the inflammasome after central nervous system (CNS) injury and stroke, as well as the basic knowledge we have gained so far regarding inflammasome activation in the CNS. In addition, we discuss some of the therapies available or under investigation for the treatment of brain injury, spinal cord injury, and stroke.


      AIM (Absent in melanoma), ASC (Apoptosis-associated speck-like protein containing a caspase activating recruitment domain), ATP (Adenosine triphosphate), ASC (Apoptosis-associated speck-like protein containing a caspase activating recruitment domain), BACE1 (β-secretase 1), CAPS (Cryopyrin-associated periodic syndromes), CARD (Caspase activating recruitment domain), cIAP (Cytosolic inhibitor of apoptosis protein), CLR (C-type lectin receptors), CNS (Central nervous system), CSF (Cerebrospinal fluid), DAMP (Danger-associated molecular pattern), Eth-D2 (Ethidium homodimer-2), GOS (Glasgow Outcome Scale), HIV (Human immunodeficiency virus), HSP (Heat shock protein), IL (Interleukin), NLR (NOD-like receptor), NOD (Nucleotide oligomerization domain), PAMP (Pathogen-associated molecular pattern), PRR (Pattern recognition receptor), RLR (RIG-1-like receptors), rtPA (Recombinant tissue plasminogen activator), SGT1 (suppressor of G2 allele of skp1), TLR (Toll-like receptors), XIAP (X-linked inhibitor of apoptosis protein)
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