Review Article| Volume 167, ISSUE 1, P80-87, January 2016

Angiogenic factors and inflammation in steroid-refractory acute graft-vs-host disease

  • Shernan G. Holtan
    Reprint requests: Shernan G. Holtan, Department of Medicine, Division of Hematology, Oncology, and Transplantation, Blood and Marrow Transplant Program, University of Minnesota, 420 Delaware Street SE, MMC 480, Minneapolis, MN 55455
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minn
    Search for articles by this author
  • Mukta Arora
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minn
    Search for articles by this author
      Steroid-refractory acute graft-vs-host disease (aGVHD) remains a frequent and often fatal complication of allogeneic hematopoietic cell transplantation. Recent evidence suggests that angiogenic factors—growth factors that contribute to blood vessel development—may be involved in tissue healing and restitution after inflammatory insults such as aGVHD. However, some angiogenic factors may also be involved in inflammation and worsen clinical outcomes. In this review, we summarize the data relevant to angiogenic factors that may contribute to healing after aGVHD (epidermal growth factor and vascular endothelial growth factor A) and angiogenic factors that may promote inflammation after aGVHD (placental growth factor and follistatin). It is currently unknown whether changes in these factors are a cause or a consequence of aGVHD. Mechanistic studies in the coming years will clarify their roles and identify new pathways for improving outcomes in steroid-refractory aGVHD.


      aGVHD (acute GraftVSHost Disease), CR (Complete response), EGF (Epidermal growth factor), EGFR (The EGF receptor), FS (Follistatin), GI (Gastrointestinal), HCT (Hematopoietic Cell transplantation), IL (Interleukin), ILC2 (Innante Lymphoid type 2 cells), ILCs (Innate Lymphoid cells), IV (Intravenous), PLGF (Placental growth factor), TNF-a (Tumor necrosis factor alpha), Treg (Regulatory T Cells), VEGF-A (Vascular endothelial growth fact A)
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