Vaccines hold promise both for the prevention of infections and as potential immunologic
therapy for patients with autoimmune disease (AD). These patients are at high risk
for both common and opportunistic infections, but this risk can be significantly reduced
and even obviated with the use of recommended available vaccines. Unfortunately, patients
with ADs are not routinely offered or provided indicated vaccinations and have higher
rates of complications from vaccine-preventable illnesses than patients without ADs.
In addition, vaccine therapy is currently under study for the treatment of autoimmune
disorders, with early studies demonstrating immunomodulatory effects that may counter
undesired immune activation and alleviate disease activity.
Abbreviations:
IS (immunosuppressive), AD (autoimmune disease), HIV (human immunodeficiency virus), PCP (pneumocystis pneumonia), VE (vaccine efficacy), ANCA (antineutrophil cytoplasmatic antibodies), SLE (systemic lupus erythematosus), ASIA (autoimmune inflammatory syndrome induced by adjuvants), ACIP (Advisory Committee on Immunization Practices), CDC (Centers for Disease Control and Prevention), EULAR (the European League Against Rheumatism), ACR (American College of Rheumatology), MMR (mumps, measles, rubella), GBS (Guillain–Barré syndrome), CAPITA (Community Acquired Pneumonia Immunization Trial in Adults), TNF (tumor necrosis factor), HZ (herpes zoster), IBD (inflammatory bowel disease), MMRV (measles, mumps, rubella and varicella vaccine), SLEDAI (Systemic Lupus Erythematosus Disease Activity Index), HPV (human papillomavirus), RA (rheumatoid arthritis), HBV (hepatitis B virus), EAE (experimental autoimmune encephalomyelitis), IL-10 (interleukin 10), TGF (transforming growth factor), DM (diabetes mellitus), Tdap (tetanus, diphtheria and acellular pertussis vaccine), Hib (Haemophillus influenza type b vaccine), IgM (immunoglobulin M), PSV23 (pneumococcal polysaccharide vaccine against 23 types of pneumococcal bacteria), PCV13 (pneumococcal conjugate vaccine against 13 types of pneumococcal bacteria), TCV (T-cell vaccination), MS (multiple sclerosis), RNP (ribonucleoprotein), DC (dendritic cell), RNA (ribonucleic acid), PBV (peptide-based vaccination), APLs (altered peptide ligands), IgG (immunoglobulin G), MBP (myelin basic protein)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: September 05, 2015
Accepted:
August 28,
2015
Received in revised form:
August 27,
2015
Received:
May 2,
2015
Footnotes
Kathleen Maksimowicz-McKinnon: Department of Medicine, Division of Rheumatology, New Center One, Suite 800, Henry Ford Hospital, 3031 W. Grand Blvd, Detroit, MI, 48202, USA [email protected]
Identification
Copyright
© 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
