A special section in this issue of Translational Research focuses on an area of human biology—mast cells (MCs)—and the diseases resulting from
MC dysfunction. Of hematopoietic origin, MCs soon leave the marrow (and other tissues
where MC progenitors reside), circulate briefly, and migrate into peripheral tissues
where they live for several to many years. Although MCs preferentially site (typically
sparsely and quiescently) at environmental interfaces and around vessels, no tissue
is absent of these heavily granulated cells which react to insults and other stimuli
mainly by expressing potent mediators prestored in granules and synthesized on demand.
MCs principally serve to defend the host and guide tissue growth and development.
Long recognized as central to allergy, MC dysfunction has been relegated to mere niches
in many other medical domains, principally due to the presumed rarity of other “serious”
(eg, malignant) forms of MC disease.
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Article info
Publication history
Published online: March 09, 2016
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© 2016 Elsevier Inc. All rights reserved.
