The microbiome and human disease pathogenesis: how do you do what you do to me …?

  • Edward N. Janoff
    Reprint requests: Edward N. Janoff, Mucosal and Vaccine Research Program Colorado (MAVRC), Research Complex 2, Room 11-012, Box B-168, Aurora, CO 80045
    Mucosal and Vaccine Research Program Colorado (MAVRC), Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo

    Denver, Veterans Affairs Medical Center, Denver, Colo
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Published:October 19, 2016DOI:
      In 1963, the English pop band, Gerry and the Pacemakers, musically inquired of their lover, “How do you do what you do to me? I wish I knew.” Over 50 years later, in the context of our current romance with the microbiome and human disease pathogenesis, we are asking the same question, and we are beginning to get answers. This timely special issue of Translational Research provides evidence that weighs these epidemiologic and mechanistic links in a range of common clinical scenarios affecting multiple organ systems and large populations.
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