Development of chimeric antigen receptor (CAR) T cells have led to remarkable successes
in the treatment of B-cell malignancies with anti-CD19 CAR. Here we discuss the development
of novel antigen receptors for use in solid malignancies with respect to target antigens,
receptor design, and T cell manipulations.
Abbreviations:
CAR (chimeric antigen receptor), HLA (human leukocyte antigen), MHC (major histocompatibility complex), NCI CTCAE (National Cancer Institute Common Terminology Criteria for Adverse Events), NSG (NOD scid gamma), PBL (peripheral blood lymphocytes), RECIST (Response Evaluation Criteria in Solid Tumors), scFv (single chain variable fragment), TCR (T cell receptor)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: June 01, 2017
Accepted:
May 23,
2017
Received in revised form:
May 22,
2017
Received:
February 24,
2017
Identification
Copyright
Published by Elsevier Inc.
