Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination
is a post-translational modification that modulates protein half-life and function
and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung
injury can progress to acute respiratory distress syndrome that is characterized by
an inflammatory response and disruption of the alveolocapillary barrier resulting
in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role
in the pathobiology of acute lung injury as it regulates the proteins modulating the
alveolocapillary barrier and the inflammatory response. Better understanding of the
signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches
by targeting specific elements of the ubiquitination pathways.
Abbreviations:
AJ (adherens junctions), ALI (acute lung injury), AMPK (adnosine monophosphate activated protein kinase), ARDS (acute respiratory distress syndrome), ATP (adenosine triphosphate), CFTR (cystic fibrosis transmembrane conductance regulator), cIAP (cellular inhibitor of apoptosis), CLR (cullin-RING ubiquitin ligase), ENaC (epithelial sodium channel), GSK3 (glycogen synthase kinase-3), HECT (homologous to the E6-AP C-terminus), HIF-1α (hypoxia-inducible factor 1α), HOIL-1L (Hemeoxidized IRP2 ubiquitin ligase 1L), HOIP (HOIL-1L interactin protein), IFN-γ (interferon gamma), IKK (IκB kinase), IL (interleukin), LUBAC (linear ubiquitination assembly complex), Met1 (N-terminal methionine), Nedd (neural precursor cell expressed developmentally downregulated protein), NEMO (NF-κB essential modulator), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), PKCζ (protein kinase C-zeta), RBR (ring in between ring), RING (really interesting new genes), RIPK1 (receptor-interacting serine-threonine kinase 1), SCF (skp1–Cullin–F-box protein), SHARPIN (SHANK-associated RH domain interacting protein), SUMO (small ubiquitin-like modifier), TAK1 (transforming growth factor-β-activated kinase 1), TJ (tight junctions), TNFα-R (tumor necrosis factor α-receptor), TNFR1-SC (TNFR1-signaling complex), TLR (toll like receptors), TRAF2 (TNFR-associated factor 2), Ub (ubiquitin), UBC13 (ubiquitin-conjugating13)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: April 23, 2018
Accepted:
April 16,
2018
Received in revised form:
April 15,
2018
Received:
February 23,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
