Liquid biopsies examine tumor cells or tumor genomic content in circulating fluids.
In advanced prostate cancer which metastasizes frequently to the bone, it is difficult
to evaluate underlying and evolving genomic heterogeneity of skeletal metastases for
effecting clinical care for which reason liquid biopsies offer an alternate approach.
In this review, we will summarize the current state of a wide variety of liquid biopsy-based
biomarker assays currently being investigated and developed for managing prostate
cancer. We will also highlight technical and clinical challenges and opportunities
for translating liquid biopsies into clinical applications.
Abbreviations:
ARSIs (androgen receptor signaling inhibitors), AA (abiraterone acetate), AR (androgen receptor), BPH (benign prostatic hyperplasia), CNV (copy number variation), CRPC (castration resistant prostate cancer), CTC (circulating tumor cells), ctDNA (cell-free circulating tumor DNA), DNA (deoxyribo nucleic acid), DRE (digital rectal examination), E (enzalutamide), EpCAM (epithelial cell adhesion molecule), LBD (ligand-binding domain), mCRPC (metastatic castration resistant prostate cancer), mRNAs (messenger ribonucleic acid), miRNAs (micro ribonucleicacid), NGS (next generation sequencing), NHT (novel hormonal therapy), PARP (poly ADP ribose polymerase), PCa (prostate cancer), PSA (prostate specific antigen), qRT-PCR (quantitative reverse transcriptase polymerase chain reaction), RNA (ribonucleic acid), RAF (rapidly accelerated fibrosarcoma)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: May 31, 2018
Accepted:
May 24,
2018
Received in revised form:
May 22,
2018
Received:
March 29,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.