The traditional view of mitochondria as isolated, spherical, energy producing organelles,
is undergoing a revolutionary change. Emerging data show that mitochondria form a
dynamic reticulum that is regulated by cycles of fission and fusion. The discovery
of proteins that modulate these activities has led to important advances in understanding
human disease. Here, we review the latest evidence that connects the emerging field
of mitochondrial dynamics to skeletal muscle insulin resistance and propose some potential
mechanisms that may explain the long debated link between mitochondria and the development
of type 2 diabetes.
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Article info
Publication history
Published online: August 01, 2018
Accepted:
July 23,
2018
Received in revised form:
July 8,
2018
Received:
May 12,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
